MicroRNAs as Potential Biomarkers of Environmental Exposure to Polycyclic Aromatic Hydrocarbons and Their Link with Inflammation and Lung Cancer

Primer Autor
Letelier, Pablo
Co-autores
Saldias, Rolando
Loren, Pia
Riquelme, Ismael
Guzman, Neftali
Título
MicroRNAs as Potential Biomarkers of Environmental Exposure to Polycyclic Aromatic Hydrocarbons and Their Link with Inflammation and Lung Cancer
Editorial
MDPI
Revista
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lenguaje
en
Resumen
Exposure to atmospheric air pollution containing volatile organic compounds such as polycyclic aromatic hydrocarbons (PAHs) has been shown to be a risk factor in the induction of lung inflammation and the initiation and progression of lung cancer. MicroRNAs (miRNAs) are small single-stranded non-coding RNA molecules of similar to 20-22 nucleotides that regulate different physiological processes, and their altered expression is implicated in various pathophysiological conditions. Recent studies have shown that the regulation of gene expression of miRNAs can be affected in diseases associated with outdoor air pollution, meaning they could also be useful as biomarkers of exposure to environmental pollution. In this article, we review the published evidence on miRNAs in relation to exposure to PAH pollution and discuss the possible mechanisms that may link these compounds with the expression of miRNAs.
Fecha Publicación
2023
Tipo de Recurso
artículo de revisión
doi
10.3390/ijms242316984
Formato Recurso
PDF
Palabras Claves
polycyclic aromatic hydrocarbons
pulmonary cancer
lung cancer
microRNAs
particulate matter
Ubicación del archivo
http://dx.doi.org/10.3390/ijms242316984
Categoría OCDE
Bioquímica y biología molecular
Química
Materias
hidrocarburos aromáticos policíclicos
cáncer de pulmón
microARN
materia particular
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
versión publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:001117832600001
ISSN
1661-6596
Tipo de ruta
verde# dorado
Categoría WOS
Bioquímica y biología molecular
Química
Referencia del Financiador (Mandatado si es aplicable-repetible)
UCT
Colecciones
Colección Publicaciones Científicas
Colección ANID
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