Repositorio
Institucional

Roa, Juan Carlos

Gloria Ili, Carmen

Brebi, Priscilla

Tapia, Oscar

Sandoval, Alejandra

Lopez, Jaime

Garcia, Patricia

Leal, Pamela

Sidransky, David

Guerrero-Preston, Rafael

Cellular FLICE-like Inhibitory Protein Long Form (c-FLIPL) Overexpression is Related to Cervical Cancer Progression

LIPPINCOTT WILLIAMS & WILKINS

INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY

en

Cervical cancer is a leading cause of cancer deaths in women worldwide and infection by high-risk human papillomavirus types is a precursor event. The cellular FLICE-like inhibitory protein (c-FLIP) has been found to be overexpressed in several types of cancers and could be associated with cervical cancer progression because of its ability to inhibit the apoptotic process. To detect c-FLIP expression in cervical cancer, an immunohistochemical staining was performed, using tissue microarrays, on a series of 536 archival biopsy samples, including normal cervical tissues, low-grade and high-grade squamous intraepithelial lesions, and squamous cervical carcinomas. The epithelium in the normal cervix and low-grade squamous intraepithelial lesions mainly stained negatively for c-FLIP, whereas high-grade intraepithelial lesions and cancer samples showed an elevated expression of c-FLIP. A direct association was observed between the increasing grade of the lesion and the intensity of c-FLIP staining, in which the frequency of intense c-FLIP expression increased from 12.5% in the normal tissue to 82.1% in the cervical cancer tissue. An increased expression of c-FLIP may be an important factor in the progression of cervical cancer. This finding could aid in identifying patients with preneoplastic lesions at greater risk of developing cervical cancer. c-FLIP expression in cervical tissue may be a potential cervical cancer progression marker.

Artículo original

This research was supported in parts by: CORFO No 07CN13PBT, CORFO No 09CN14-5960 (CEGIN), FONDECYT postdoctoral proyect No312014.

Esta investigación fue financiada en parte por: CORFO No 07CN13PBT, CORFO No 09CN14-5960 (CEGIN), proyecto postdoctoral FONDECYT No312014.

10.1097/PGP.0b013e31825d8064

pdf

c-FLIP

Cervical cancer

Immunohistochemestry

FAS-MEDIATED APOPTOSIS

CASPASE-8 ACTIVATION

HUMAN-PAPILLOMAVIRUS

EXPRESSION

DEATH

REGULATOR

HODGKIN

GRADE

CELLS

c-FLIP

Cáncer de cuello uterino

Inmunohistoquímica

APOPTOSIS MEDIADA POR FAS

ACTIVACIÓN DE LA CASPASA-8

VIRUS DEL PAPILOMA HUMANO

EXPRESIÓN

MUERTE

REGULADOR

HODGKIN

GRADO

CÉLULAS

c-FLIP

Cervical cancer

Immunohistochemestry

FAS-MEDIATED APOPTOSIS

CASPASE-8 ACTIVATION

HUMAN-PAPILLOMAVIRUS

EXPRESSION

DEATH

REGULATOR

HODGKIN

GRADE

CELLS

c-FLIP

Cáncer de cuello uterino

Inmunohistoquímica

APOPTOSIS MEDIADA POR FAS

ACTIVACIÓN DE LA CASPASA-8

VIRUS DEL PAPILOMA HUMANO

EXPRESIÓN

MUERTE

REGULADOR

HODGKIN

GRADO

CÉLULAS

Oncología

Patología

Biotecnología Relacionada con la Salud

Cellular FLICE-like Inhibitory Protein Long Form (c-FLIPL) Overexpression is Related to Cervical Cancer Progression

INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY

hibrida

verde

metadata

metadata

PMID 23518915

en

Artículo original

versión publicada

CORFO 07CN13PBT#CORFO 09CN14-5960 (CEGIN)

ANID CONICYT FONDECYT 312014

Academy of Finland (AKA) 312014

CORFO 07CN13PBT

CORFO 09CN14-5960 (CEGIN)

ANID CONICYT FONDECYT 312014

Academy of Finland (AKA) 312014

LIPPINCOTT WILLIAMS & WILKINS

0277-1691

316

322

Obstetricia y Ginecología

Patología

Obstetrics & Gynecology

Pathology

pdf

WOS:000317482300009