Repositorio UFRO · Omeka S

Validation of a novel algorithm for quantification of the percentage of signal fractionation in atrial fibrillation

Primer Autor	Redfearn, Damian P.
Co-autores	Haley, Charlotte L. Gula, Lorne J. Miranda, Rodrigo Michael, Kevin A. Baranchuk, Adrian M. Simpson, Christopher S. Abdollah, Hoshiar West, Adam J. Akl, Selim G.
Título	Validation of a novel algorithm for quantification of the percentage of signal fractionation in atrial fibrillation
Editorial	OXFORD UNIV PRESS
Revista	EUROPACE
Lenguaje	en
Resumen	Aims Catheter ablation for paroxysmal atrial fibrillation (AF) is rapidly becoming a standard practice. There is literature to support that catheter ablation of persistent AF requires additional 'substrate modification'. In clinical practice, operators rely on automated fractionation maps created by three-dimensional anatomic mapping systems to rapidly assess complex 'fractionated' signals (CFAE). These systems use differing algorithms to automate the process. The agreement between operators and contemporary algorithms has not been examined. We sought to assess the agreement between operators and a novel method of quantification calculating percentage fractionation (PF). Methods and results Expert opinion on 80 atrial electrogram 4 s signals of varying levels of activity were gathered and pooled for comparison. Twelve independent experts visually quantified the signal fractionation and offered a threshold level for ablation. We developed an algorithm to find sites with high continuous electrical activity, or high PF. Correlation between experts and PF was 0.78 [P < 0.01, 95% confidence interval (CI) (0.68-0.86)]. Receiver operating characteristics curve sensitivity and specificity for PF were 0.7727 and 0.8103 at the optimal cut-off point of 58.45 PF with area under curve 0.89 CI (0.80-0.99). Conclusion The PF statistic represents a more robust and intuitive measure to represent fractionated atrial activity; importantly it demonstrates excellent agreement with expert users and presents a new standard for algorithm assessment Use of a PF statistic should be considered in automated mapping systems.
Tipo de Recurso	Artículo original
doi	10.1093/europace/eus361
Formato Recurso	pdf
Palabras Claves	Fractionation Complex fractionated atrial electrograms Atrial fibrillation Ablation FREQUENCY-DOMAIN CHARACTERISTICS CATHETER ABLATION COMPLEX ELECTROGRAMS TERMINATION SUBSTRATE AF MULTICENTER STRATEGY SINUS CFAE Fraccionamiento Electrogramas auriculares fraccionados complejos Fibrilación auricular Ablación CARACTERÍSTICAS DEL DOMINIO DE LA FRECUENCIA ABLACIÓN POR CATÉTER ELECTROGRAMAS COMPLEJOS TERMINACIÓN SUSTRATO FA MULTICENTRO ESTRATEGIA SENO CFAE
Ubicación del archivo	http://dx.doi.org/10.1093/europace/eus361
Materias	Fractionation Complex fractionated atrial electrograms Atrial fibrillation Ablation FREQUENCY-DOMAIN CHARACTERISTICS CATHETER ABLATION COMPLEX ELECTROGRAMS TERMINATION SUBSTRATE AF MULTICENTER STRATEGY SINUS CFAE Fraccionamiento Electrogramas auriculares fraccionados complejos Fibrilación auricular Ablación CARACTERÍSTICAS DEL DOMINIO DE LA FRECUENCIA ABLACIÓN POR CATÉTER ELECTROGRAMAS COMPLEJOS TERMINACIÓN SUSTRATO FA MULTICENTRO ESTRATEGIA SENO CFAE
Disciplinas de la OCDE	Sistema Cardiovascular y Cardiaco Cirugía
Título de la cita (Recomendado-único)	Validation of a novel algorithm for quantification of the percentage of signal fractionation in atrial fibrillation
Revista/Libro	EUROPACE
Tipo de ruta	hibrida verde
Access Rights	acceso abierto
Derechos de acceso	acceso abierto
Identificador alternativo	PMID 23154844
Idioma	en
Identificador del recurso (Mandatado-único)	Artículo original
Versión del recurso (Recomendado-único)	versión publicada
Editorial	OXFORD UNIV PRESS
ISSN	1099-5129
Página de inicio (Recomendado-único)	447
Página final (Recomendado-único)	452
Categoría WOS	Sistemas cardíacos y cardiovasculares Cardiac & Cardiovascular Systems
Formato	pdf
Id de Web of Science	WOS:000316537800029