Cellular and molecular mechanisms in the hypoxic tissue: role of HIF-1 and ROS

Primer Autor
Farias, Jorge G.
Co-autores
Zepeda, Andrea B.
Pessoa, Adalberto, Jr.
Castillo, Rodrigo L.
Figueroa, Carolina A.
Pulgar, Victor M.
Título
Cellular and molecular mechanisms in the hypoxic tissue: role of HIF-1 and ROS
Editorial
WILEY
Revista
CELL BIOCHEMISTRY AND FUNCTION
Lenguaje
en
Resumen
Reactive oxygen species such as superoxide anion radicals (O-2(-)) and hydrogen peroxide (H2O2) have for long time been recognized as undesirable by-products of the oxidative mitochondrial generation of adenosine triphosphate (ATP). Recently, these highly reactive species have been associated to important signaling pathways in diverse physiological conditions such as those activated in hypoxic microenvironments. The molecular response to hypoxia requires fast-acting mechanisms acting within a wide range of partial pressures of oxygen (O-2). Intracellular O-2 sensing is an evolutionary preserved feature, and the best characterized molecular responses to hypoxia are mediated through transcriptional activation. The transcription factor, hypoxia-inducible factor 1 (HIF-1), is a critical mediator of these adaptive responses, and its activation by hypoxia involves O-2-dependent posttranslational modifications and nuclear translocation. Through the induction of the expression of its target genes, HIF-1 coordinately regulates tissue O-2 supply and energetic metabolism. Other transcription factors such as nuclear factor B are also redox sensitive and are activated in pro-oxidant and hypoxic conditions. The purpose of this review is to summarize new developments in HIF-mediated O-2 sensing mechanisms and their interactions with reactive oxygen species-generating pathways in normal and abnormal physiology. Copyright (c) 2013 John Wiley & Sons, Ltd.
Tipo de Recurso
Artículo de revisión
Description
The authors acknowledge the financial support of Comision Nacional de Investigacion Cientifica y Tecnologica de Chile (CONICYT) doctoral fellowship to ABZ (Chile), DI-UFRO (Universidad de la Frontera) 11-4001 (JGF), 12-2007 FAPESP (SAo Paulo Research Foundation, Brazil) (AP and JGF) and Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT) grant no. 11110426 (RLC).
The authors acknowledge the financial support of Comision Nacional de Investigacion Cientifica y Tecnologica de Chile (CONICYT) doctoral fellowship to ABZ (Chile), DI-UFRO (Universidad de la Frontera) 11-4001 (JGF), 12-2007 FAPESP (SAo Paulo Research Foundation, Brazil) (AP and JGF) and Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT) grant no. 11110426 (RLC).
doi
10.1002/cbf.2985
Formato Recurso
pdf
Palabras Claves
oxidative stress
hypoxia-inducible factor (HIF-1)
nuclear factor B (NF-B)
hypoxic tissue
reactive oxygen species
UNFOLDED PROTEIN RESPONSE
ENDOTHELIAL GROWTH-FACTOR
OXIDATIVE STRESS
NITRIC-OXIDE
INTERMITTENT HYPOXIA
HYPOBARIC HYPOXIA
FREE-RADICALS
OXYGEN
GENE
DEGRADATION
estrés oxidativo
factor inducible por hipoxia (HIF-1)
factor nuclear B (NF-B)
tejido hipóxico
especies reactivas de oxígeno
RESPUESTA A PROTEÍNAS DESPLEGADAS
FACTOR DE CRECIMIENTO ENDOTELIAL
ESTRÉS OXIDATIVO
ÓXIDO NÍTRICO
HIPOXIA INTERMITENTE
HIPOXIA HIPOBÁRICA
RADICALES LIBRES
OXÍGENO
GEN
DEGRADACIÓN
Ubicación del archivo
http://dx.doi.org/10.1002/cbf.2985
Materias
oxidative stress
hypoxia-inducible factor (HIF-1)
nuclear factor B (NF-B)
hypoxic tissue
reactive oxygen species
UNFOLDED PROTEIN RESPONSE
ENDOTHELIAL GROWTH-FACTOR
OXIDATIVE STRESS
NITRIC-OXIDE
INTERMITTENT HYPOXIA
HYPOBARIC HYPOXIA
FREE-RADICALS
OXYGEN
GENE
DEGRADATION
estrés oxidativo
factor inducible por hipoxia (HIF-1)
factor nuclear B (NF-B)
tejido hipóxico
especies reactivas de oxígeno
RESPUESTA A PROTEÍNAS DESPLEGADAS
FACTOR DE CRECIMIENTO ENDOTELIAL
ESTRÉS OXIDATIVO
ÓXIDO NÍTRICO
HIPOXIA INTERMITENTE
HIPOXIA HIPOBÁRICA
RADICALES LIBRES
OXÍGENO
GEN
DEGRADACIÓN
Disciplinas de la OCDE
Biología Celular
Bioquímica
Fisiología
Título de la cita (Recomendado-único)
Cellular and molecular mechanisms in the hypoxic tissue: role of HIF-1 and ROS
Revista/Libro
CELL BIOCHEMISTRY AND FUNCTION
Tipo de ruta
hibrida
verde
Access Rights
metadata
Derechos de acceso
metadata
Identificador alternativo
PMID 23760768
Idioma
en
Identificador del recurso (Mandatado-único)
Artículo de revisión
Versión del recurso (Recomendado-único)
versión publicada
Entidad financiadora
ANID CONICYT #UFRO 11-4001, 12-2007#FAPESP (SAo Paulo Research Foundation, Brazil)#ANID CONICYT FONDECYT 11110426
Referencia del Financiador (Mandatado si es aplicable-repetible)
ANID CONICYT
UFRO 11-4001, 12-2007
FAPESP (SAo Paulo Research Foundation, Brazil)
ANID CONICYT FONDECYT 11110426
Editorial
WILEY
ISSN
0263-6484
Página de inicio (Recomendado-único)
451
Página final (Recomendado-único)
459
Categoría WOS
Bioquímica y biología molecular
biología celular
Biochemistry & Molecular Biology
Cell Biology
Formato
pdf
Id de Web of Science
WOS:000321757700002
Colecciones
Colección Publicaciones Científicas
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