Repositorio UFRO · Omeka S

Melatonin Protective Role in Mouse Cauda Epipidymal Spermatozoa Damage Induced by Sodium Arsenite

Primer Autor	Bustos-Obregon, Eduardo
Co-autores	Poblete, Daniel Catriao, Roberto del Sol, Mariano Henrique Fernandes, Fabio
Título	Melatonin Protective Role in Mouse Cauda Epipidymal Spermatozoa Damage Induced by Sodium Arsenite
Editorial	SOC CHILENA ANATOMIA
Revista	INTERNATIONAL JOURNAL OF MORPHOLOGY
Lenguaje	en
Resumen	We evaluated the sperm parameters such as cauda epididymis weight, sperm count, sperm morphology and sperm DNA stability of adult CF-1 male mice treated daily (oral exposure) with the toxic sodium arsenite (As, 7.0 mg/kg/body weight); Melatonin (Me, 10.0 mg/kg/bw), Me (10.0 mg/kg/bw) plus As (7.0 mg/kg/bw) and Negative Control (NaCl 0.9%) to assess acute (8.3 days), chronic (33.2 days) and recovery of testicular damage (66.4 days). Arsenic decreases the number of sperm from chronic treatment (33.2 days) and this effect continued until 66.4 days of treatment. The toxic effect of As also altered the morphology of spermatozoa in all treatment periods when compared to the negative control group. However, Metalonin induced protective effects in periods of 33.2 and 66.4 days of treatment. Additionally, the stability of DNA was significantly affected by arsenic in all periods, but the chronic treatment (33.2 days) in the AsMe revealed increased stability compared to the group treated with arsenic only. Melatonin partially protects sperm toxicity caused by Arsenic, especially during periods of 33.2 and 66.4 days.
Tipo de Recurso	Artículo original
doi	10.4067/S0717-95022013000400017
Formato Recurso	pdf
Palabras Claves	Mouse Melatonin Arsenic Sperm DNA stability OXIDATIVE STRESS SERTOLI-CELLS ANTIOXIDANT ERYTHROCYTES TOXICITY FERTILE AGENTS SEMEN MODE DNA Ratón Melatonina Arsénico Espermatozoides Estabilidad del ADN ESTRÉS OXIDATIVO CÉLULAS DE SERTOLI ANTIOXIDANTE ERITROCITOS TOXICIDAD FÉRTIL AGENTES SEMEN MODO ADN
Ubicación del archivo	http://dx.doi.org/10.4067/S0717-95022013000400017
Materias	Mouse Melatonin Arsenic Sperm DNA stability OXIDATIVE STRESS SERTOLI-CELLS ANTIOXIDANT ERYTHROCYTES TOXICITY FERTILE AGENTS SEMEN MODE DNA Ratón Melatonina Arsénico Espermatozoides Estabilidad del ADN ESTRÉS OXIDATIVO CÉLULAS DE SERTOLI ANTIOXIDANTE ERITROCITOS TOXICIDAD FÉRTIL AGENTES SEMEN MODO ADN
Disciplinas de la OCDE	Toxicología Biología Reproductiva
Título de la cita (Recomendado-único)	Melatonin Protective Role in Mouse Cauda Epipidymal Spermatozoa Damage Induced by Sodium Arsenite
Revista/Libro	INTERNATIONAL JOURNAL OF MORPHOLOGY
Tipo de ruta	dorada verde
Access Rights	acceso abierto
Derechos de acceso	acceso abierto
License	CC BY-NC
Condición de la licencia (Recomendado-repetible)	CC BY-NC
Idioma	en
Identificador del recurso (Mandatado-único)	Artículo original
Versión del recurso (Recomendado-único)	versión publicada
Editorial	SOC CHILENA ANATOMIA
ISSN	0717-9502
Página de inicio (Recomendado-único)	1251
Página final (Recomendado-único)	1256
Categoría WOS	Anatomía y morfología Anatomy & Morphology
Formato	pdf
Id de Web of Science	WOS:000332286400017