Repositorio UFRO · Omeka S

Oral lichen planus treated with tacrolimus 0.1%

Primer Autor	Olate, Sergio
Co-autores	Marinho Resende, Joao Paulo Afonso Miranda Chaves, Maria das Gracas Aarestrup, Fernando Monteiro Aarestrup, Beatriz Vieira Netto, Henrique Duque
Título	Oral lichen planus treated with tacrolimus 0.1%
Editorial	E-CENTURY PUBLISHING CORP
Revista	INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
Lenguaje	en
Resumen	Oral lichen planus (OLP) is considered a chronic autoimmune inflammatory disease and its presence may be related to increased emotional stress. The clinical relevance of OLP is the possibility of developing a squamous cell carcinoma, the etiology of which is still unknown. The aim of this study is to treat OLP lesions resistant to conventional treatment with corticosteroids, using topical tacrolimus 0.1% (Protopic (R)) twice a day for a period of eight weeks. Fifteen patients were selected who had filled out a history form and a visual analog scale for pain before and after treatment. All patients underwent an initial biopsy to diagnose the disease and another at the end of the treatment period to evaluate the effect of the medication on the infiltrate. A weekly check was carried out, observing the clinical appearance, pain symptoms and occurrence of side effects which, where present, were mild and transient. The results showed twelve patients (80%) with total or nearly total remission of pain symptoms and lesions, two patients (13.33%) showed clearer lesions and only one patient (6.67%) had no change in clinical symptoms or pain. Histopathological analysis showed OLP had a moderate or strong regression in twelve patients (80%) and an absent or mild regression in three patients (20%). Based on these results, it was concluded that tacrolimus 0.1% (Protopic (R)) is a safe and effective medication that improves the clinical appearance of the lesion, reduces pain as well as the histopathological features of OLP.
Tipo de Recurso	Artículo original
doi	PMID: 24260597
Formato Recurso	pdf
Palabras Claves	Oral lichen planus tacrolimus treatment recalcitrant corticosteroids TOPICAL TACROLIMUS OINTMENT THERAPY SERIES Liquen plano oral tacrolimus tratamiento resistente corticosteroides TACROLIMUS TÓPICO UNGÜENTO TERAPIA SERIE
Ubicación del archivo	http://dx.doi.org/PMID: 24260597
Materias	Oral lichen planus tacrolimus treatment recalcitrant corticosteroids TOPICAL TACROLIMUS OINTMENT THERAPY SERIES Liquen plano oral tacrolimus tratamiento resistente corticosteroides TACROLIMUS TÓPICO UNGÜENTO TERAPIA SERIE
Disciplinas de la OCDE	Odontología, Cirugía y Medicina Oral Farmacología y Farmacia
Título de la cita (Recomendado-único)	Oral lichen planus treated with tacrolimus 0.1%
Revista/Libro	INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
Tipo de ruta	diamante verde
Access Rights	acceso abierto
Derechos de acceso	acceso abierto
Identificador alternativo	PMID 24260597
Idioma	en
Identificador del recurso (Mandatado-único)	Artículo original
Versión del recurso (Recomendado-único)	versión publicada
Editorial	E-CENTURY PUBLISHING CORP
ISSN	1940-5901
Página de inicio (Recomendado-único)	917
Página final (Recomendado-único)	921
Categoría WOS	Medicina, Investigación y Experimentación Medicine, Research & Experimental
Formato	pdf
Id de Web of Science	WOS:000327588200007