Repositorio UFRO · Omeka S

Efficacy of red light alone and methyl-aminolaevulinate-photodynamic therapy for the treatment of mild and moderate facial acne

Primer Autor	Schafer, Fabiola
Co-autores	Pinto, Cristian Orellana, Juan Jose Gonzalez, Sergio Hasson, Ariel
Título	Efficacy of red light alone and methyl-aminolaevulinate-photodynamic therapy for the treatment of mild and moderate facial acne
Editorial	WOLTERS KLUWER MEDKNOW PUBLICATIONS
Revista	INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
Lenguaje	en
Resumen	Background: Photodynamic therapy (PDT) has been shown to be an effective alternative for acne. However, there is little information comparing the efficacy of red light alone and methyl aminolaevulinate (MAL)-PDT. Aims: To compare the efficacy and tolerability of red light alone and MAL-PDT in patients with mild to moderate facial acne. Methods: Thirty six patients with mild to moderate acne were enrolled. Eighteen patients recieved MAL-PDT and 18 received red light alone in two sessions, 2 weeks apart. Acne grade and lesion counts were assessed by blinded evaluators at baseline, 2, 4 and 10 weeks. Results: At week 2, clinical improvement from acne grade II-IV to 0-I was observed in 82.3% of MAL-PDT group and 14.2% of red light alone group. Red light alone group had a gradual clinical improvement over time with a 77% response at week 10. In contrast, MAL-PDT group had a rapid clinical improvement with total response at week 10. Both treatments were significantly effective for improving acne lesions. However, MAL-PDT group had a greater response (P < 0.001). Histologically, decreased amounts of sebocytes and lipids along with atrophic sebaceous glands were observed after MAL-PDT. Conclusion: MAL-PDT has a quicker onset of action with a higher response than red light alone. MAL-PDT may induce a reduction in the size of the sebaceous glands and then long-term acne remission.
Tipo de Recurso	Artículo original
doi	10.4103/0378-6323.104673
Formato Recurso	pdf
Palabras Claves	Acne vulgaris methyl aminolevulinate photodynamic therapy red light VULGARIS ACID PHOTOTHERAPY BASICS Acné vulgar aminolevulinato de metilo terapia fotodinámica luz roja VULGARIS ÁCIDO FOTOTERAPIA CONCEPTOS BÁSICOS
Ubicación del archivo	http://dx.doi.org/10.4103/0378-6323.104673
Materias	Acne vulgaris methyl aminolevulinate photodynamic therapy red light VULGARIS ACID PHOTOTHERAPY BASICS Acné vulgar aminolevulinato de metilo terapia fotodinámica luz roja VULGARIS ÁCIDO FOTOTERAPIA CONCEPTOS BÁSICOS
Disciplinas de la OCDE	Dermatología y Enfermedades Venéreas Biotecnología Relacionada con la Salud
Título de la cita (Recomendado-único)	Efficacy of red light alone and methyl-aminolaevulinate-photodynamic therapy for the treatment of mild and moderate facial acne
Revista/Libro	INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
Tipo de ruta	diamante verde
Access Rights	acceso abierto
Derechos de acceso	acceso abierto
Identificador alternativo	PMID 23254733
Idioma	en
Identificador del recurso (Mandatado-único)	Artículo original
Versión del recurso (Recomendado-único)	versión publicada
Editorial	WOLTERS KLUWER MEDKNOW PUBLICATIONS
ISSN	0378-6323
Página de inicio (Recomendado-único)	77
Página final (Recomendado-único)	82
Categoría WOS	Dermatología Dermatology
Formato	pdf
Id de Web of Science	WOS:000313292900012