Repositorio
Institucional

Farias, Jorge G.

Jimenez, Daniel

Osorio, Jorge

Zepeda, Andrea B.

Figueroa, Carolina A.

Pulgar, Victor M.

Acclimatization to chronic intermittent hypoxia in mine workers: a challenge to mountain medicine in Chile

SOC BIOLGIA CHILE

BIOLOGICAL RESEARCH

en

In the past two decades, Chile has developed intense mining activity in the Andes mountain range, whose altitude is over 4,000 meters above sea level. It is estimated that a workforce population of over 55,000 is exposed to high altitude hypobaric hypoxia. The miners work under shift systems which vary from 4 to 20 days at the worksite followed by rest days at sea level, in a cycle repeated for several years. This Chronic Intermittent Hypoxia (CIH) constitutes an unusual condition for workers involving a series of changes at the physiological, cellular and molecular levels attempting to compensate for the decrease in the environmental partial pressure of oxygen (PO2). The mine worker must become acclimatized to CIH, and consequently undergoes an acute acclimatization process when he reaches the worksite and an acute reverse process when he reaches sea level. We have observed that after a period of 3 to 8 years of CIH exposure workers acclimatize well, and evidence from our studies and those of others indicates that CIH induces acute and chronic multisystem adjustments which are effective in offsetting the reduced availability of oxygen at high altitudes. The aims of this review are to summarize findings of the physiological responses to CIH exposure, highlighting outstanding issues in the field.

Artículo original

The authors are sincerely thankful for the support provided by DIUFRO grant DI12-2007 and CONICYT PhD Fellowship Program.

Los autores agradecen sinceramente el apoyo brindado por la beca DIUFRO DI12-2007 y el Programa de Becas de Doctorado CONICYT.

10.4067/S0716-97602013000100009

pdf

High Altitude

Mine Workers

Intermittent Hypoxia

Acclimatization

Chilean Model

HIGH-ALTITUDE EXPOSURE

HYPOBARIC HYPOXIA

OXIDATIVE STRESS

LIPID-PEROXIDATION

PULMONARY-HYPERTENSION

CARDIOVASCULAR-SYSTEM

EXERCISE

BLOOD

MUSCLE

HEART

Altitud elevada

mineros

hipoxia intermitente

aclimatación

modelo chileno

EXPOSICIÓN A GRAN ALTITUD

HIPOXIA HIPOBÁRICA

ESTRÉS OXIDATIVO

PEROXIDACIÓN LIPÍDICA

HIPERTENSIÓN PULMONAR

SISTEMA CARDIOVASCULAR

EJERCICIO

SANGRE

MÚSCULO

CORAZÓN

High Altitude

Mine Workers

Intermittent Hypoxia

Acclimatization

Chilean Model

HIGH-ALTITUDE EXPOSURE

HYPOBARIC HYPOXIA

OXIDATIVE STRESS

LIPID-PEROXIDATION

PULMONARY-HYPERTENSION

CARDIOVASCULAR-SYSTEM

EXERCISE

BLOOD

MUSCLE

HEART

Altitud elevada

mineros

hipoxia intermitente

aclimatación

modelo chileno

EXPOSICIÓN A GRAN ALTITUD

HIPOXIA HIPOBÁRICA

ESTRÉS OXIDATIVO

PEROXIDACIÓN LIPÍDICA

HIPERTENSIÓN PULMONAR

SISTEMA CARDIOVASCULAR

EJERCICIO

SANGRE

MÚSCULO

CORAZÓN

Fisiología

Salud Pública y Ambiental

Minería y Procesamiento de Minerales

Acclimatization to chronic intermittent hypoxia in mine workers: a challenge to mountain medicine in Chile

BIOLOGICAL RESEARCH

dorada

verde

acceso abierto

acceso abierto

CC BY NC 4.0

PMID 23760416

en

Artículo original

versión publicada

UFRO DI12-2007#ANID CONICYT

UFRO DI12-2007

ANID CONICYT

SOC BIOLGIA CHILE

0716-9760

59

67

Biología

Biology

pdf

WOS:000317541300009