Prognostic validation of a non-laboratory and a laboratory based cardiovascular disease risk score in multiple regions of the world

Primer Autor
Joseph, Philip
Co-autores
Yusuf, Salim#Lee, Shun Fu#Ibrahim, Quazi#Teo, Koon#Rangarajan, Sumathy#Gupta, Rajeev#Rosengren, Annika#Lear, Scott A.#Avezum, Alvaro#Lopez-Jaramillo, Patricio#Gulec, Sadi#Yusufali, Afzalhussein#Chifamba, Jephat#Lanas, Fernando#Kumar, Rajesh#Mohammadifard, Noushin#Mohan, Viswanathan#Mony, Prem#Kruger, Annamarie#Liu, Xu#Guo, Baoxia#Zhao, Wenqi#Yang, Youzhu#Pillai, Rajamohanan#Diaz, Rafael#Krishnapillai, Ambigga#Iqbal, Romaina#Yusuf, Rita#Szuba, Andrzej#Anand, Sonia S.
Título
Prognostic validation of a non-laboratory and a laboratory based cardiovascular disease risk score in multiple regions of the world
Editorial
BMJ PUBLISHING GROUP
Revista
HEART
Lenguaje
en
Resumen
Objective To evaluate the performance of the non-laboratory INTERHEART risk score (NL-IHRS) to predict incident cardiovascular disease (CVD) across seven major geographic regions of the world. The secondary objective was to evaluate the performance of the fasting cholesterol-based IHRS (FC-IHRS). Methods Using measures of discrimination and calibration, we tested the performance of the NL-IHRS (n=100475) and FC-IHRS (n=107863) for predicting incident CVD in a community-based, prospective study across seven geographic regions: South Asia, China, Southeast Asia, Middle East, Europe/North America, South America and Africa. CVD was defined as the composite of cardiovascular death, myocardial infarction, stroke, heart failure or coronary revascularisation. Results Mean age of the study population was 50.53 (SD 9.79) years and mean follow-up was 4.89 (SD 2.24) years. The NL-IHRS had moderate to good discrimination for incident CVD across geographic regions (concordance statistic (C-statistic) ranging from 0.64 to 0.74), although recalibration was necessary in all regions, which improved its performance in the overall cohort (increase in C-statistic from 0.69 to 0.72, p<0.001). Regional recalibration was also necessary for the FC-IHRS, which also improved its overall discrimination (increase in C-statistic from 0.71 to 0.74, p<0.001). In 85078 participants with complete data for both scores, discrimination was only modestly better with the FC-IHRS compared with the NL-IHRS (0.74 vs 0.73, p<0.001). Conclusions External validations of the NL-IHRS and FC-IHRS suggest that regionally recalibrated versions of both can be useful for estimating CVD risk across a diverse range of community-based populations. CVD prediction using a non-laboratory score can provide similar accuracy to laboratory-based methods.
Tipo de Recurso
Artículo original
doi
10.1136/heartjnl-2017-311609
Formato Recurso
pdf
Palabras Claves
cardiovascular disease# risk prediction# INTERHEART risk score
Ubicación del archivo
http://dx.doi.org/10.1136/heartjnl-2017-311609
Categoría OCDE
Cardiac & Cardiovascular Systems
Materias
enfermedad cardiovascular# predicción de riesgos# Puntuación de riesgo INTERHEART
Disciplinas de la OCDE
Sistema Cardiovascular y Cardiaco
Epidemiología
Otros Temas de Medicina Clínica
Id de Web of Science
WOS:000428908800009
Título de la cita (Recomendado-único)
Prognostic validation of a non-laboratory and a laboratory based cardiovascular disease risk score in multiple regions of the world
Identificador del recurso (Mandatado-único)
Artículo original
Versión del recurso (Recomendado-único)
version publicada
Editorial
BMJ PUBLISHING GROUP
Revista/Libro
HEART
Categoría WOS
Sistemas cardíacos y cardiovasculares
ISSN
1355-6037
Idioma
en
Formato
pdf
Tipo de ruta
dorada#verde
Access Rights
acceso abierto
Derechos de acceso
acceso abierto
License
CC BY-NC 4.0
Colecciones
Colección Publicaciones Científicas
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