Feasibility of dose enhancement assessment: Preliminary results by means of Gd-infused polymer gel dosimeter and Monte Carlo study

Primer Autor
Santibanez, M.
Co-autores
Guillen, Y.#Chacon, D.#Figueroa, R. G.#Valente, M.
Título
Feasibility of dose enhancement assessment: Preliminary results by means of Gd-infused polymer gel dosimeter and Monte Carlo study
Editorial
PERGAMON-ELSEVIER SCIENCE LTD
Revista
APPLIED RADIATION AND ISOTOPES
Lenguaje
en
Resumen
This work reports the experimental development of an integral Gd-infused dosimeter suitable for Gd dose enhancement assessment along with Monte Carlo simulations applied to determine the dose enhancement by radioactive and X-ray sources of interest in conventional and electronic brachytherapy. In this context, capability to elaborate a stable and reliable Gd-infused dosimeter was the first goal aimed at direct and accurate measurements of dose enhancement due to Gd presence. Dose-response was characterized for standard and Gd-infused PAGAT polymer gel dosimeters by means of optical transmission/absorbance. The developed Gd-infused PAGAT dosimeters demonstrated to be stable presenting similar dose-response as standard PAGAT within a linear trend up to 13 Gy along with good post-irradiation readout stability verified at 24 and 48 h. Additionally, dose enhancement was evaluated for Gd-infused PAGAT dosimeters by means of Monte Carlo (PENELOPE) simulations considering scenarios for isotopic and X-ray generator sources. The obtained results demonstrated the feasibility of obtaining a maximum enhancement around of (14 +/- 1)% for Ir-192 source and an average enhancement of (70 +/- 13)% for Am-241. However, dose enhancement up to (267 +/- 18)% may be achieved if suitable filtering is added to the Am-241 source. On the other hand, optimized X-ray spectra may attain dose enhancements up to (253 +/- 22) %, which constitutes a promising future alternative for replacing radioactive sources by implementing electronic brachytherapy achieving high dose levels.
Tipo de Recurso
artículo original#presentación de congreso
Description
This work has been supported by the CONICYT program through FONDECYT grant No. 11150673.
Este trabajo ha sido apoyado por el programa CONICYT a través del fondo FONDECYT No. 11150673.
doi
10.1016/j.apradiso.2018.04.016
Formato Recurso
pdf
Palabras Claves
Gd dose enhancement# PAGAT gel dosimetry# Electronic Brachytherapy
Ubicación del archivo
http://doi.org/10.1016/j.apradiso.2018.04.016
Categoría OCDE
Chemistry, Inorganic & Nuclear# Nuclear Science & Technology# Radiology, Nuclear Medicine & Medical Imaging
Materias
aumento de la dosis de Gd# dosimetría en gel PAGAT# Braquiterapia Electrónica
Disciplinas de la OCDE
Física Nuclear
Ingeniería Médica
Otras Especialidades de la Física
Id de Web of Science
WOS:000449448300035
Título de la cita (Recomendado-único)
Feasibility of dose enhancement assessment: Preliminary results by means of Gd-infused polymer gel dosimeter and Monte Carlo study
Identificador relacionado
http://hdl.handle.net/11336/91583
Identificador del recurso (Mandatado-único)
artículo original#presentación de congreso
Versión del recurso (Recomendado-único)
version publicada
Editorial
PERGAMON-ELSEVIER SCIENCE LTD
Revista/Libro
APPLIED RADIATION AND ISOTOPES
Categoría WOS
Química, Inorgánica y Nuclear# Ciencia y tecnología nucleares# Radiología, Medicina Nuclear e Imágenes Médicas
ISSN
0969-8043
Idioma
en
Referencia del Financiador (Mandatado si es aplicable-repetible)
ANID FONDECYT 11150673
ANID CONICYT FONDECYT 11150673
Descripción
This work has been supported by the CONICYT program through FONDECYT grant No. 11150673.
Formato
pdf
Tipo de ruta
hibrida#verde
Access Rights
metadata
Derechos de acceso
metadata
Página de inicio (Recomendado-único)
196
Página final (Recomendado-único)
203
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