Repositorio
Institucional

Vedelago, Jose

Gomez, Cesar G.#Valente, Mauro#Mattea, Facundo

Green synthesis of silver nanoparticles aimed at improving theranostics

PERGAMON-ELSEVIER SCIENCE LTD

RADIATION PHYSICS AND CHEMISTRY

en

Nowadays, the combination of diagnosis and therapy, known as theranostics, is one of the keys for an optimal treatment for cancer diseases. Theranostics can be significantly improved by incorporating metallic nano particles that are specifically delivered and accumulated in cancerous tissue. In this context, precise knowledge about dosimetric effects in nanoparticle-infused tissues as well as the detection and processing of emerging radiation are extremely important issues. In the last years the first studies on theranostic nanomaterials in gel dosimetry have been presented but there is still a broad field of study to explore. Most of gel dosimetric materials are extremely sensible to modifications in their composition, the addition of enhancers, metallic or inorganic charges can alter their stability and dosimetric properties, therefore, thorough studies must be made before the incorporation of any type of modifier. In this work, the synthesis of metallic nanoparticles suitable for gel dosimetry for x-ray applications is presented. A green synthesis process of silver nanoparticles coated with porcine skin gelatin by thermal reduction of silver nitrate is presented. Nanoparticles were obtained and purified for their application in gel dosimetry. Also, nanoparticles size distribution, reaction yield and the preliminar application as theranostic agents were tested in Fricke gel dosimetry in the keV range. The obtained nano particles were successfully used in theranostic applications acting as fluorescent agents and dose enhancers in Xray beam irradiation simultaneously.

Artículo original

Authors thank the financial support by CONICET from the Project ESPORA I - PIP 11220130100658CO and PIP 11220110100499CO project, and SeCyT-UNC by means of 30720150101410CB and 30820150100348CB projects, DOSCOM I (30720150101109CB) project and INSPIRATE I (30920150100380CB) program. This work was also partially supported by Universidad de La Frontera by DIUFRO DI 6008-16 and DI 17-1003 projects.

Los autores agradecen el apoyo financiero del CONICET a través de los proyectos ESPORA I (PIP 11220130100658CO y PIP 11220110100499CO), y de la SeCyT-UNC a través de los proyectos 30720150101410CB y 30820150100348CB, el proyecto DOSCOM I (30720150101109CB) y el programa INSPIRATE I (30920150100380CB). Este trabajo también contó con el apoyo parcial de la Universidad de La Frontera a través de los proyectos DIUFRO DI 6008-16 y DI 17-1003.

10.1016/j.radphyschem.2018.01.001

pdf

Ag NPs# Green synthesis# TEM# X-ray# Theranostics

http://dx.doi.org/10.1016/j.radphyschem.2018.01.001

Chemistry, Physical# Nuclear Science & Technology# Physics, Atomic, Molecular & Chemical

NP agrícolas# Síntesis verde# TEM# Radiografía# teranóstica

Tecnología Médica

Nanomateriales (Producción y Propiedades)

Oncología

WOS:000428487600009

Green synthesis of silver nanoparticles aimed at improving theranostics

Artículo original

version publicada

PERGAMON-ELSEVIER SCIENCE LTD

RADIATION PHYSICS AND CHEMISTRY

Química Física# Ciencia y tecnología nucleares# Física, Atómica, Molecular y Química

0969-806X

en

CONICET ESPORA I - PIP 11220130100658CO#CONICET ESPORA I - PIP 11220110100499CO#SeCyT UNC 30720150101410CB#SeCyT UNC 30820150100348CB#DOSCOM I 30720150101109CB#INSPIRATE I 30920150100380CB#UFRO DI 6008-16#UFRO DI 17-1003

CONICET ESPORA I PIP 11220130100658CO

CONICET ESPORA I PIP 11220110100499CO

SeCyT-UNC 30720150101410CB

SeCyT-UNC 30820150100348CB

DOSCOM I 30720150101109CB

INSPIRATE I 30920150100380CB

UFRO DI 6008-16

UFRO DI 17-1003

Authors thank the financial support by CONICET from the Project ESPORA I - PIP 11220130100658CO and PIP 11220110100499CO project, and SeCyT-UNC by means of 30720150101410CB and 30820150100348CB projects, DOSCOM I (30720150101109CB) project and INSPIRATE I (30920150100380CB) program. This work was also partially supported by Universidad de La Frontera by DIUFRO DI 6008-16 and DI 17-1003 projects.

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hibrida#verde

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