Repositorio
Institucional

Haidar, Ziyad S.

Zumaran, Consuelo C.#Parra, Marcelo V.#Olate, Sergio A.#Fernandez, Eduardo G.#Munoz, Francisco T.

"The 3 R's for Platelet-Rich Fibrin: A ""Super"" Tri-Dimensional Biomaterial for Contemporary Naturally-Guided Oro-Maxillo-Facial Soft and Hard Tissue Repair, Reconstruction and Regeneration"

MDPI

MATERIALS

en

"Platelet-Rich fibrin (PRF) is a three-dimensional (3-D) autogenous biomaterial obtained via simple and rapid centrifugation from the patient's whole blood samples, without including anti-coagulants, bovine thrombin, additives, or any gelifying agents. At the moment, it is safe to say that in oral and maxillofacial surgery, PRFs (particularly, the pure platelet-rich fibrin or P-PRF and leukocyte and platelet-rich fibrin or L-PRF sub-families) are receiving the most attention, essentially because of their simplicity, cost-effectiveness, and user-friendliness/malleability, they are a fairly new ""revolutionary"" step in second-generation therapies based on platelet concentration, indeed. Yet, the clinical effectiveness of such surgical adjuvants or regenerative platelet concentrate-based preparations continues to be highly debatable, primarily as a result of preparation protocol variability, limited evidence-based clinical literature, and/or poor understanding of bio-components and clinico-mechanical properties. To provide a practical update on the application of PRFs during oral surgery procedures, this critical review focuses on evidence obtained from human randomized and controlled clinical trials only. The aim is to serve the reader with current information on the clinical potential, limitations, challenges, and prospects of PRFs. Accordingly, reports often associate autologous PRFs with early bone formation and maturation, accelerated soft-tissue healing, and reduced post-surgical edema, pain, and discomfort. An advanced and original tool in regenerative dentistry, PRFs present a strong alternative and presumably cost-effective biomaterial for oro-maxillo-facial tissue (soft and hard) repair and regeneration. Yet, preparation protocols continue to be a source of confusion, thereby requiring revision and standardization. Moreover, to increase the validity, comprehension, and therapeutic potential of the reported findings or observations, a decent analysis of the mechanico-rheological properties, bio-components, and their bioactive function is eagerly needed and awaited, afterwards, the field can progress toward a brand-new era of ""super"" oro-dental biomaterials and bioscaffolds for use in oral and maxillofacial tissue repair and regeneration, and beyond."

Artículo de revisión

Generous funding and operating grants supported this work by providing to the BioMAT'X Research Group, part of CIIB (Centro de Investigacion e Innovacion Biomedica), through the Faculty of Dentistry and PMI (Plan de Mejoramiento Institucional en Innovacion I+D+i), Department for Research, Development and Innovation, Universidad de los Andes, Santiago de Chile. The corresponding author (Z.S.H.) acknowledges supplementary operating funding provided from CONICYT-FONDEF Chile under awarded project/grant (national) #ID16I10366 (2016-2019) and Fondo de Ayuda a la Investigacion FAI-Universidad de los Andes No. INV-IN-2015-101 (2015-2019). This work is related with the ongoing R&D&I project nanoL-PRF at BioMAT'X.

10.3390/ma11081293

pdf

tissue engineering# regeneration# leukocyte# platelet# fibrin# growth factors# dentistry# oral surgery# periodontology# osteogenesis# grafts

tissue engineering# regeneration# leukocyte# platelet# fibrin# growth factors# dentistry# oral surgery# periodontology# osteogenesis# grafts

http://dx.doi.org/10.3390/ma11081293

Chemistry, Physical# Materials Science, Multidisciplinary# Metallurgy & Metallurgical Engineering# Physics, Applied# Physics, Condensed Matter

ingeniería de tejidos# regeneración# leucocito# plaqueta# fibrina# factores de crecimiento# odontología# cirugía bucal# periodoncia# osteogénesis# injertos

ingeniería de tejidos# regeneración# leucocito# plaqueta# fibrina# factores de crecimiento# odontología# cirugía bucal# periodoncia# osteogénesis# injertos

WOS:000444112800030

"The 3 R's for Platelet-Rich Fibrin: A ""Super"" Tri-Dimensional Biomaterial for Contemporary Naturally-Guided Oro-Maxillo-Facial Soft and Hard Tissue Repair, Reconstruction and Regeneration"

Artículo de revisión

version publicada

MDPI

MATERIALS

Química Física# Ciencia de Materiales, Multidisciplinaria# Metalurgia e Ingeniería Metalúrgica# Física Aplicada# Física, Materia Condensada

en

BioMAT'X Research Group#Universidad de los Andes#ANID CONICYT-FONDEF Chile ID16I10366 Universidad de los Andes FAI INV-IN-2015-101

Generous funding and operating grants supported this work by providing to the BioMAT'X Research Group, part of CIIB (Centro de Investigacion e Innovacion Biomedica), through the Faculty of Dentistry and PMI (Plan de Mejoramiento Institucional en Innovacion I+D+i), Department for Research, Development and Innovation, Universidad de los Andes, Santiago de Chile. The corresponding author (Z.S.H.) acknowledges supplementary operating funding provided from CONICYT-FONDEF Chile under awarded project/grant (national) #ID16I10366 (2016-2019) and Fondo de Ayuda a la Investigacion FAI-Universidad de los Andes No. INV-IN-2015-101 (2015-2019). This work is related with the ongoing R&D&I project nanoL-PRF at BioMAT'X.

pdf

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