Antibiotic activity of Emerimicin IV isolated from Emericellopsis minima from Talcahuano Bay, Chile
| Primer Autor |
Silva, Mario
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| Co-autores |
Inostroza, Alejandro#Lara, Liliana#Paz, Cristian#Perez, Andres#Galleguillos, Felipe#Hernandez, Victor#Becerra, Jose#Gonzalez-Rocha, Gerardo
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| Título |
Antibiotic activity of Emerimicin IV isolated from Emericellopsis minima from Talcahuano Bay, Chile
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| Editorial |
TAYLOR & FRANCIS LTD
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| Revista |
NATURAL PRODUCT RESEARCH
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| Lenguaje |
en
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| Resumen |
Due to the increasing emergence of resistance of bacterial pathogens to current antibiotics, we have examined the marine fungi present in sea sediments obtained 200m offshore to discover new antibacterial compounds active against multidrug-resistant bacteria. One strain, identified as Emericellopsis minima, was isolated from sediments of Talcahuano Bay (Chile). From the liquid culture of E. minima, we isolated Emerimicin IV, a unique fungal peptaibol that exhibited antibacterial activity. The structure of this compound was assigned by interpretation of H-1 NMR and HR-LCMS data. Emerimicin IV showed bacteriostatic activity against clinical isolates of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis with MIC values ranging between 100 and 12.5g/mL. [GRAPHICS]
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| Tipo de Recurso |
Artículo original
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| Description |
This work was supported by FONDECYT [grant number 1120924], Direccion de Investigacion, Universidad de Concepcion [grant number Enlace No 215.111.060-1.0].
|
| doi |
10.1080/14786419.2017.1344655
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| Formato Recurso |
pdf
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| Palabras Claves |
Marine-derived fungi# Emericellopsis minima# Emerimicin IV# antibacterial activity# multidrug-resistant bacteria
Marine-derived fungi# Emericellopsis minima# Emerimicin IV# antibacterial activity# multidrug-resistant bacteria
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| Ubicación del archivo |
http://dx.doi.org/10.1080/14786419.2017.1344655
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| Categoría OCDE |
Chemistry, Applied# Chemistry, Medicinal
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| Materias |
Hongos de origen marino# Emericellopsis mínima# emerimicina IV# actividad antibacteriana# bacterias multirresistentes
Hongos de origen marino# Emericellopsis mínima# emerimicina IV# actividad antibacteriana# bacterias multirresistentes
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| Id de Web of Science |
WOS:000430051100024
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| Título de la cita (Recomendado-único) |
Antibiotic activity of Emerimicin IV isolated from <i>Emericellopsis minima</i> from Talcahuano Bay, Chile
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| Identificador del recurso (Mandatado-único) |
Artículo original
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| Versión del recurso (Recomendado-único) |
version publicada
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| Editorial |
TAYLOR & FRANCIS LTD
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| Revista/Libro |
NATURAL PRODUCT RESEARCH
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| Categoría WOS |
Química Aplicada# Química, Medicinal
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| ISSN |
1478-6419
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| Idioma |
en
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| Referencia del Financiador (Mandatado si es aplicable-repetible) |
ANID FONDECYT 1120924#UdeC Enlace 215.111.060-1.0
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| Descripción |
This work was supported by FONDECYT [grant number 1120924], Direccion de Investigacion, Universidad de Concepcion [grant number Enlace No 215.111.060-1.0].
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| Formato |
pdf
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| Tipo de ruta |
suscripción
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| Access Rights |
metadata
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| Derechos de acceso |
metadata
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| Página de inicio (Recomendado-único) |
1230
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| Página final (Recomendado-único) |
1232
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