Repositorio
Institucional

Farias, Jorge G.

Lee-Estevez, Manuel#Figueroa, Elias#Cosson, Jacky#Short, Stefania E.#Valdebenito, Ivan#Ulloa-Rodriguez, Patricio

Zebrafish as a useful model for immunological research with potential applications in aquaculture

WILEY

REVIEWS IN AQUACULTURE

en

The Zebrafish (Danio Rerio) is a Teleost fish, which offers several practical advantages concerning manipulation, maintenance and versatility as well as short life cycle, low cost and physiological similarity with most farmed species. Zebrafish have been used as model for several aquaculture-relevant infectious agents, since the cost of infections to aquaculture can be great, making failure of immunity a major risk for commercial fish farming. This have allowed scientist to understand pathogens biology as well as fish immune response against infection, and thus have helped to improve disease control in aquaculture. This review summarizes the recent reports and main knowledge concerning the cellular and molecular aspects of the immune response in zebrafish and its potential applications in the fish farming industry. Several research results in zebrafish and other teleosts reveal that mucosal tissues have a strong and well-structured immune response involving both innate and adaptive components. Together with the advantages of low maintenance cost, easy handling and genetic tools available, zebrafish comes up as a useful and reliable animal model for invivo study of fish immune response and mechanisms as well as fish-affecting infectious and inflammatory diseases which are a cause of concern for the aquaculture industry. Also, vaccines development, drugs screening and immunologically focused fish food assessment seem to be promising fields where zebrafish model can be used to generate positive impacts to the aquaculture practice.

Artículo de revisión

"Special thanks to Dr. William Shelton (Research Institute of Fish Culture and Hydrobiology, Faculty of Fisheries and Protection of Waters, University of South Bohemia, Ceske Budejovice, Czech Republic) for his help in editing the manuscript. The study was financially supported by the following sources: Project FONDECYT No. 1151315, Grants for Ph.D studies in Chile, Ministry of Education, Youth and Sports of the Czech Republic - projects ""CENAKVA"" (No. CZ.1.05/2.1.00/01.0024), ""CENAKVA II"" (No. LO1205 under the NPU I program) and COST (No. LD14119), Grant Agency of the University of South Bohemia in Ceske Budejovice (No. 114/2013/Z), the Czech Science Foundation (P502/15-12034S) and partially funded by COST Office (Food and Agriculture COST Action FA1205: AQUAGAMETE)."

"Un agradecimiento especial al Dr. William Shelton (Instituto de Investigación de Cultivo de Peces e Hidrobiología, Facultad de Pesca y Protección de Aguas, Universidad de Bohemia del Sur, Ceske Budejovice, República Checa) por su ayuda en la edición del manuscrito. El estudio fue financiado por las siguientes fuentes: Proyecto FONDECYT No. 1151315, Becas para estudios de doctorado en Chile, Ministerio de Educación, Juventud y Deportes de la República Checa - proyectos ""CENAKVA"" (No. CZ.1.05/2.1.00/01.0024), ""CENAKVA II"" (No. LO1205 bajo el programa NPU I) y COST (No. LD14119), Agencia de Becas de la Universidad de Bohemia del Sur en Ceske Budejovice (No. 114/2013/Z), la Fundación Checa para la Ciencia (P502/15-12034S) y parcialmente financiado por la Oficina COST (Acción FA1205 de COST para la Alimentación y la Agricultura: AQUAGAMETE).

Special thanks to Dr. William Shelton (Research Institute of Fish Culture and Hydrobiology, Faculty of Fisheries and Protection of Waters, University of South Bohemia, Ceske Budejovice, Czech Republic) for his help in editing the manuscript. The study was financially supported by the following sources: Project FONDECYT No. 1151315, Grants for Ph.D studies in Chile, Ministry of Education, Youth and Sports of the Czech Republic - projects ""CENAKVA"" (No. CZ.1.05/2.1.00/01.0024), ""CENAKVA II"" (No. LO1205 under the NPU I program) and COST (No. LD14119), Grant Agency of the University of South Bohemia in Ceske Budejovice (No. 114/2013/Z), the Czech Science Foundation (P502/15-12034S) and partially funded by COST Office (Food and Agriculture COST Action FA1205: AQUAGAMETE)."

10.1111/raq.12156

pdf

aquaculture# immune response# mucosal immunity# mucosal vaccination# Zebrafish

http://dx.doi.org/10.1111/raq.12156

Fisheries

acuicultura# respuesta inmune# inmunidad mucosa# vacunación mucosa# pez cebra

Pesca

Inmunología

Zoología, Ornitología, Entomología y Comportamiento Biológico

WOS:000428462500013

Zebrafish as a useful model for immunological research with potential applications in aquaculture

Artículo de revisión

version publicada

WILEY

REVIEWS IN AQUACULTURE

Pesca

1753-5123

en

University of South Bohemia 114/2013/Z#ANID FONDECYT 1151315#Ministry of Education, Youth and Sports of the Czech Republic CZ.1.05/2.1.00/01.0024#Ministry of Education, Youth and Sports of the Czech Republic CENAKVA II LO1205#Ministry of Education, Youth and Sports of the Czech Republic LD14119#Czech Science Foundation P502/15-12034S#Food and Agriculture COST FA1205

"ANID FONDECYT 1151315

Ministry of Education, Youth and Sports of the Czech Republic CENAKVA"" CZ.1.05/2.1.00/01.0024

Ministry of Education, Youth and Sports of the Czech Republic CENAKVA II LO1205

Ministry of Education, Youth and Sports of the Czech Republic COST LD14119

University of South Bohemia in Ceske Budejovice 114/2013/Z

Czech Science Foundation P502/15-12034S

COST Office (Food and Agriculture COST Action FA1205: AQUAGAMETE)"

"Special thanks to Dr. William Shelton (Research Institute of Fish Culture and Hydrobiology, Faculty of Fisheries and Protection of Waters, University of South Bohemia, Ceske Budejovice, Czech Republic) for his help in editing the manuscript. The study was financially supported by the following sources: Project FONDECYT No. 1151315, Grants for Ph.D studies in Chile, Ministry of Education, Youth and Sports of the Czech Republic - projects ""CENAKVA"" (No. CZ.1.05/2.1.00/01.0024), ""CENAKVA II"" (No. LO1205 under the NPU I program) and COST (No. LD14119), Grant Agency of the University of South Bohemia in Ceske Budejovice (No. 114/2013/Z), the Czech Science Foundation (P502/15-12034S) and partially funded by COST Office (Food and Agriculture COST Action FA1205: AQUAGAMETE)."

pdf

hibrida

metadata

metadata