Circulating Levels of Inflammatory Proteins and Survival in Patients with Gallbladder Cancer

Primer Autor
Liu, Zhiwei
Co-autores
Kemp, Troy J.#Gao, Yu-Tang#Corbel, Amanda#McGee, Emma E.#Carlos Roa, Juan#Wang, Bingsheng#Carlos Araya, Juan#Shen, Ming-Chang#Rashid, Asif#Hsing, Ann W.#Hildesheim, Allan#Ferreccio, Catterina#Pfeiffer, Ruth M.#Pinto, Ligia A.#Koshiol, Jill
Título
Circulating Levels of Inflammatory Proteins and Survival in Patients with Gallbladder Cancer
Editorial
NATURE PORTFOLIO
Revista
SCIENTIFIC REPORTS
Lenguaje
en
Resumen
Although inflammation is central to gallbladder cancer (GBC) development and proliferation, no study has systematically investigated circulating inflammatory proteins and patient survival. We aimed to examine whether the circulating levels of inflammatory proteins is associated with all-cause mortality among such patients. We recruited 134 patients with newly diagnosed with GBC from 1997 to 2001 in a population-based study in Shanghai and an independent set of 35 patients from 2012 to 2013 in Chile. Cox proportional hazards regression models adjusted for covariates were used to evaluate the hazard ratios (HRs) for death by serum levels of 49 inflammatory proteins (quartiles). Of 49 evaluable proteins, eight were significantly associated with overall survival. Seven were associated with a poorer survival, while the highest levels of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) were associated with an increase in survival (HR = 0.26, 95% CI = 0.14, 0.47). No substantial difference in the magnitude of the association was observed between early-and late-stages of GBC. Of seven proteins, five were validated in the patients from Chile. Reducing inflammation and targeting pathways associated with increased survival might improve GBC outcomes. The potential for using a TRAIL-related anticancer drug for GBC treatment merits further investigation.
Tipo de Recurso
Artículo original
doi
10.1038/s41598-018-23848-8
Formato Recurso
pdf
Ubicación del archivo
http://dx.doi.org/10.1038/s41598-018-23848-8
Categoría OCDE
Oncology
Id de Web of Science
WOS:000429095600080
Título de la cita (Recomendado-único)
Circulating Levels of Inflammatory Proteins and Survival in Patients with Gallbladder Cancer
Identificador del recurso (Mandatado-único)
Artículo original
Versión del recurso (Recomendado-único)
version publicada
Editorial
NATURE PORTFOLIO
Revista/Libro
SCIENTIFIC REPORTS
Categoría WOS
Oncología# Nutrición y dietética
ISSN
2045-2322
Idioma
en
Formato
pdf
Tipo de ruta
dorada#verde
Access Rights
acceso abierto
Derechos de acceso
acceso abierto
License
CC BY
Página de inicio (Recomendado-único)
866
Página final (Recomendado-único)
878
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