Evaluation of substantivity of hypochlorous acid as an antiplaque agent: A randomized controlled trial

Primer Autor
Lafaurie, G. I.
Co-autores
Zaror, C.#Diaz-Baez, D.#Castillo, D. M.#De Avila, J.#Trujillo, T. G.#Calderon-Mendoza, J.
Título
Evaluation of substantivity of hypochlorous acid as an antiplaque agent: A randomized controlled trial
Editorial
WILEY
Revista
INTERNATIONAL JOURNAL OF DENTAL HYGIENE
Lenguaje
en
Resumen
Background: Hypochlorous acid (HOCl) is a non-antibiotic antimicrobial substance with significant effects on pathogenic oral micro-organisms. The effects of HOCl as an antiplaque agent have not been studied. Objective: The aim of this study was to evaluate the substantivity of HOCl mouthwashes compared with chlorhexidine (CHX) rinses and a placebo. Materials and Methods: A double-blind randomized controlled trial with 75 participants was conducted. Participants were divided into five groups using block randomization: 0.025% HOCl, 0.05% HOCl, 0.12% CHX, 0.2% CHX, and sterile water as a placebo. Participants were instructed to use each rinse solution for 30 seconds after dental prophylaxis. Samples of saliva were taken at baseline and after 30 seconds, 1, 3, 5 and 7 hours to assess substantivity, and bacterial viability was established by the fluorescence method. Visible plaque in all participants was assessed with the Turesky index at baseline and at 7 hours, and adverse events were also assessed. Results: HOCl led to a 33% reduction in bacterial counts in the saliva after 30 seconds compared with a 58% reduction by CHX. HOCl has no substantivity, and bacterial counts returned to baseline after 1 hour. Placebo treatment led to the highest plaque count after 7 hours compared with the CHX and HOCl groups, although the differences were not significant. HOCl rinsing induced the highest percentages of unpleasant taste and dryness sensations. Conclusions: HOCl rinses have an initial effect on bacterial viability in saliva but have no substantivity. Other mechanisms may explain its antiplaque effect.
Tipo de Recurso
Artículo original
Description
Departamento Administrativo de Ciencia, Tecnologia e Innovacion, Grant/Award Number: 130850227678
Departamento Administrativo de Ciencia, Tecnología e Innovación, Número de subvención/premio: 130850227678
doi
10.1111/idh.12342
Formato Recurso
pdf
Palabras Claves
antiplaque agents# chlorhexidine# hypochlorous acid# substantivity
Ubicación del archivo
http://dx.doi.org/10.1111/idh.12342
Categoría OCDE
Dentistry, Oral Surgery & Medicine
Materias
agentes antiplaca# clorhexidina# ácido hipocloroso# sustantividad
Disciplinas de la OCDE
Odontología, Cirugía y Medicina Oral
Farmacología y Farmacia
Microbiología
Id de Web of Science
WOS:000447291600013
Título de la cita (Recomendado-único)
Evaluation of substantivity of hypochlorous acid as an antiplaque agent: A randomized controlled trial
Identificador del recurso (Mandatado-único)
Artículo original
Versión del recurso (Recomendado-único)
version publicada
Editorial
WILEY
Revista/Libro
INTERNATIONAL JOURNAL OF DENTAL HYGIENE
Categoría WOS
Odontología, Cirugía Bucal y Medicina
ISSN
1601-5029
Idioma
en
Referencia del Financiador (Mandatado si es aplicable-repetible)
Colciencias 130850227678
Descripción
Departamento Administrativo de Ciencia, Tecnologia e Innovacion, Grant/Award Number: 130850227678
Formato
pdf
Tipo de ruta
hibrida
Access Rights
metadata
Derechos de acceso
metadata
Colecciones
Colección Publicaciones Científicas
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