DNA is hypomethylated in circadian manifestations of bruxism
| Primer Autor |
Oporto, G. H.
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| Co-autores |
Salazar, L. A.
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| Título |
DNA is hypomethylated in circadian manifestations of bruxism
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| Editorial |
WILEY
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| Revista |
ORAL DISEASES
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| Lenguaje |
en
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| Resumen |
ObjectiveThe aim of this study was to compare the global DNA methylation levels in patients under bruxism treatment and a control group. MethodsSubjects undergoing bruxism treatment were classified in awake bruxism (42 patients), sleep bruxism (32 patients) and both conditions (42 patients). The control group included 42 individuals. A colorimetric assay (MethylFlash Methylated DNA 5-mC Quantification Kit, Epigenetic Group Inc., NY, USA) was used to determine the global DNA methylation levels. ResultsStatistically significant differences were found in amounts of methylated DNA in all circadian manifestations of bruxism compared with a control group (sleep bruxism=0.95% 2.02%, awake bruxism=0.87% +/- 2.1%, sleep and awake bruxism=0.17% +/- 0.25%, Control=1.69% +/- 1.6%, Kruskal-Wallis test [p=.0001] followed by Dunn's test [p<.05]). ConclusionPatients undergoing bruxism treatment exhibited hypomethylated DNA levels when compared to control group. Our results suggest that DNA hypomethylation might be a novel aetiologic factor in bruxism aetiology. Further researches must be performed exploring the role of epigenetics modifications in circadian manifestations of bruxism.
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| Tipo de Recurso |
Artículo original
|
| Description |
G.H.O. was the recipient of a fellowship from CONICYT-Chile
G.H.O. fue beneficiario de una beca de CONICYT-Chile
|
| doi |
10.1111/odi.12856
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| Formato Recurso |
pdf
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| Palabras Claves |
bruxism# circadian manifestations# DNA methylation# epigenetics# facial pain
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| Ubicación del archivo |
http://dx.doi.org/10.1111/odi.12856
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| Categoría OCDE |
Dentistry, Oral Surgery & Medicine
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| Materias |
bruxismo# manifestaciones circadianas# metilación del ADN# epigenética# dolor facial
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| Disciplinas de la OCDE |
Genética y Herencia
Odontología, Cirugía y Medicina Oral
Biología Molecular
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| Id de Web of Science |
WOS:000442499600031
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| Título de la cita (Recomendado-único) |
DNA is hypomethylated in circadian manifestations of bruxism
|
| Identificador del recurso (Mandatado-único) |
Artículo original
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| Versión del recurso (Recomendado-único) |
version publicada
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| Editorial |
WILEY
|
| Revista/Libro |
ORAL DISEASES
|
| Categoría WOS |
Odontología, Cirugía Bucal y Medicina
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| ISSN |
1354-523X
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| Idioma |
en
|
| Referencia del Financiador (Mandatado si es aplicable-repetible) |
ANID CONICYT
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| Descripción |
G.H.O. was the recipient of a fellowship from CONICYT-Chile
|
| Formato |
pdf
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| Tipo de ruta |
hibrida
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| Access Rights |
metadata
|
| Derechos de acceso |
metadata
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| Página de inicio (Recomendado-único) |
358
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| Página final (Recomendado-único) |
361
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