Single nucleotide polymorphisms in genes of dopaminergic pathways are associated with bruxism

Primer Autor
Salazar, Luis A.
Co-autores
Oporto, Gonzalo H., V#Bornhardt, Thomas#Iturriaga, Veronica
Título
Single nucleotide polymorphisms in genes of dopaminergic pathways are associated with bruxism
Editorial
SPRINGER HEIDELBERG
Revista
CLINICAL ORAL INVESTIGATIONS
Lenguaje
en
Resumen
This research aimed to evaluate the frequency of single nucleotide polymorphisms (SNPs) in dopaminergic pathway genes (DRD1, DRD2, DRD3, DRD4, DRD5, and MAOB) in patients undergoing bruxism treatment and controls. Patients submitted to bruxism treatment were classified in awake bruxism (61 patients), sleep bruxism (26 patients), and awake-sleep bruxism (43 patients). Control group included 59 patients. Association between circadian manifestations of bruxism and SNPs was investigated using Fisher's exact test, chi-squared test, and calculating the odds ratios and their respective 95% confidence intervals. The G allele of DRD2 rs1800497 SNP was associated with a significant risk reduction of awake-sleep bruxism (p = 0.041), while the C allele of DRD3 rs6280 SNP was associated with increased risk of sleep bruxism (p = 0.02), and the C allele of DRD5 rs6283 SNP was associated with decreased risk of awake bruxism (p = 0.01). To our knowledge, this is the first report exploring the contribution of genetic variants in dopaminergic pathways to bruxism development, considering all circadian manifestations. Our findings indicate a possible genetic influence in the etiology of awake, sleep, and awake-sleep bruxism. Therefore, further research is needed to increase the current understanding of bruxism physiopathology.
Tipo de Recurso
Artículo original
Description
The work was supported by Direccion de Investigacion & Desarrollo (DIUFRO), Universidad de La Frontera, Temuco, Chile (DI14-0047).
El trabajo fue apoyado por la Dirección de Investigación y Desarrollo (DIUFRO), Universidad de La Frontera, Temuco, Chile (DI14-0047).
doi
10.1007/s00784-017-2117-z
Formato Recurso
pdf
Palabras Claves
Temporomandibular disorders# Molecular genetics# Neuropeptides# Neuroscience# Molecular biology# Nervous system
Ubicación del archivo
http://dx.doi.org/10.1007/s00784-017-2117-z
Categoría OCDE
Dentistry, Oral Surgery & Medicine
Materias
Trastornos temporomandibulares# Genética molecular# Neuropéptidos# Neurociencia# Biología molecular# Sistema nervioso
Disciplinas de la OCDE
Genética y Herencia
Odontología, Cirugía y Medicina Oral
Neurociencias
Id de Web of Science
WOS:000419148200031
Título de la cita (Recomendado-único)
Single nucleotide polymorphisms in genes of dopaminergic pathways are associated with bruxism
Identificador del recurso (Mandatado-único)
Artículo original
Versión del recurso (Recomendado-único)
version publicada
Editorial
SPRINGER HEIDELBERG
Revista/Libro
CLINICAL ORAL INVESTIGATIONS
Categoría WOS
Odontología, Cirugía Bucal y Medicina
ISSN
1432-6981
Idioma
en
Referencia del Financiador (Mandatado si es aplicable-repetible)
UFRO DI14-0047
Descripción
The work was supported by Direccion de Investigacion & Desarrollo (DIUFRO), Universidad de La Frontera, Temuco, Chile (DI14-0047).
Formato
pdf
Tipo de ruta
hibrida
Access Rights
restringido
Derechos de acceso
restringido
Colecciones
Colección Publicaciones Científicas
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