Combating tumor cells through SIRT3 activation and exercise

Primer Autor
Diaz, Erik
Co-autores
Carlos Borquez, Juan#Montes, Nicolas
Título
Combating tumor cells through SIRT3 activation and exercise
Editorial
SOC MEDICA SANTIAGO
Revista
REVISTA MEDICA DE CHILE
Lenguaje
es
Resumen
One of the main features of cancer is the high rate of cell proliferation and growth. To do this, cancer cells need to redirect their metabolism mainly towards anaerobic glycolysis and an increased mitochondrial glutamine energy metabolism. Sirtuins are cellular proteins with regulatory functions on metabolic pathways, genomic stability, apoptosis, longevity, inflammation, energy metabolism and oxidative stress. Sirtuins have emerged recently as a potential therapeutic option to treat several chronic diseases including cancer. This review summarizes the tumor suppressor function of Sirtuin 3 (SIRT3), highlighting its repressor effect on glycolytic metabolism, promoting mitochondrial metabolism and oxidative stress reduction. SIRT3 activation by exercise is particularly described since it may represent a potent tool for several types of cancer treatment.
Tipo de Recurso
Artículo de revisión
doi
10.4067/s0034-98872018000600762
Formato Recurso
pdf
Palabras Claves
Exercise# Neoplasms# Sirtuins
Ubicación del archivo
http://dx.doi.org/10.4067/s0034-98872018000600762
Categoría OCDE
Medicine, General & Internal
Materias
Ejercicio# Neoplasias# Sirtuinas
Disciplinas de la OCDE
Oncología
Neurociencias
Biología Molecular
Versión del recurso (Recomendado-único)
version publicada
Tipo de ruta
dorada
verde
Access Rights
acceso abierto
Derechos de acceso
acceso abierto
Id de Web of Science
WOS:000442535800010
Título de la cita (Recomendado-único)
Combating tumor cells through SIRT3 activation and exercise
Identificador del recurso (Mandatado-único)
Artículo de revisión
Editorial
SOC MEDICA SANTIAGO
Revista/Libro
REVISTA MEDICA DE CHILE
Categoría WOS
Medicina general e interna
ISSN
0034-9887
Idioma
es
Formato
pdf
Página de inicio (Recomendado-único)
362
Página final (Recomendado-único)
366
Colecciones
Colección Publicaciones Científicas
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0 visitas
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