Combating tumor cells through SIRT3 activation and exercise
| Primer Autor |
Diaz, Erik
|
| Co-autores |
Carlos Borquez, Juan#Montes, Nicolas
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| Título |
Combating tumor cells through SIRT3 activation and exercise
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| Editorial |
SOC MEDICA SANTIAGO
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| Revista |
REVISTA MEDICA DE CHILE
|
| Lenguaje |
es
|
| Resumen |
One of the main features of cancer is the high rate of cell proliferation and growth. To do this, cancer cells need to redirect their metabolism mainly towards anaerobic glycolysis and an increased mitochondrial glutamine energy metabolism. Sirtuins are cellular proteins with regulatory functions on metabolic pathways, genomic stability, apoptosis, longevity, inflammation, energy metabolism and oxidative stress. Sirtuins have emerged recently as a potential therapeutic option to treat several chronic diseases including cancer. This review summarizes the tumor suppressor function of Sirtuin 3 (SIRT3), highlighting its repressor effect on glycolytic metabolism, promoting mitochondrial metabolism and oxidative stress reduction. SIRT3 activation by exercise is particularly described since it may represent a potent tool for several types of cancer treatment.
|
| Tipo de Recurso |
Artículo de revisión
|
| doi |
10.4067/s0034-98872018000600762
|
| Formato Recurso |
pdf
|
| Palabras Claves |
Exercise# Neoplasms# Sirtuins
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| Ubicación del archivo |
http://dx.doi.org/10.4067/s0034-98872018000600762
|
| Categoría OCDE |
Medicine, General & Internal
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| Materias |
Ejercicio# Neoplasias# Sirtuinas
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| Disciplinas de la OCDE |
Oncología
Neurociencias
Biología Molecular
|
| Id de Web of Science |
WOS:000442535800010
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| Título de la cita (Recomendado-único) |
Combating tumor cells through SIRT3 activation and exercise
|
| Identificador del recurso (Mandatado-único) |
Artículo de revisión
|
| Versión del recurso (Recomendado-único) |
version publicada
|
| Editorial |
SOC MEDICA SANTIAGO
|
| Revista/Libro |
REVISTA MEDICA DE CHILE
|
| Categoría WOS |
Medicina general e interna
|
| ISSN |
0034-9887
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| Idioma |
es
|
| Formato |
pdf
|
| Tipo de ruta |
dorada#verde
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| Access Rights |
acceso abierto
|
| Derechos de acceso |
acceso abierto
|
| Página de inicio (Recomendado-único) |
362
|
| Página final (Recomendado-único) |
366
|
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