Repositorio
Institucional

Lear, Scott A.

Hu, Weihong#Rangarajan, Sumathy#Gasevic, Danijela#Leong, Darryl#Iqbal, Romaina#Casanova, Amparo#Swaminathan, Sumathi#Anjana, R. M.#Kumar, Rajesh#Rosengren, Annika#Wei, Li#Yang, Wang#Wang Chuangshi#Liu Huaxing#Nair, Sanjeev#Diaz, Rafael#Swidon, Hany#Gupta, Rajeev#Mohammadifard, Noushin#Lopez-Jaramillo, Patricio#Oguz, Aytekin#Zatonska, Katarzyna#Seron, Pamela#Avezum, Alvaro#Poirier, Paul#Teo, Koon#Yusuf, Salim

The effect of physical activity on mortality and cardiovascular disease in 130 000 people from 17 high-income, middle-income, and low-income countries: the PURE study

ELSEVIER SCIENCE INC

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en

Background Physical activity has a protective effect against cardiovascular disease (CVD) in high-income countries, where physical activity is mainly recreational, but it is not known if this is also observed in lower-income countries, where physical activity is mainly non-recreational. We examined whether different amounts and types of physical activity are associated with lower mortality and CVD in countries at different economic levels. Methods In this prospective cohort study, we recruited participants from 17 countries (Canada, Sweden, United Arab Emirates, Argentina, Brazil, Chile, Poland, Turkey, Malaysia, South Africa, China, Colombia, Iran, Bangladesh, India, Pakistan, and Zimbabwe). Within each country, urban and rural areas in and around selected cities and towns were identified to reflect the geographical diversity. Within these communities, we invited individuals aged between 35 and 70 years who intended to live at their current address for at least another 4 years. Total physical activity was assessed using the International Physical Activity Questionnaire (IPQA). Participants with pre-existing CVD were excluded from the analyses. Mortality and CVD were recorded during a mean of 6.9 years of follow-up. Primary clinical outcomes during follow-up were mortality plus major CVD (CVD mortality, incident myocardial infarction, stroke, or heart failure), either as a composite or separately. The effects of physical activity on mortality and CVD were adjusted for sociodemographic factors and other risk factors taking into account household, community, and country clustering. Findings Between Jan 1, 2003, and Dec 31, 2010, 168 916 participants were enrolled, of whom 141 945 completed the IPAQ. Analyses were limited to the 130 843 participants without pre-existing CVD. Compared with low physical activity (<600 metabolic equivalents [MET] x minutes per week or < 150 minutes per week of moderate intensity physical activity), moderate (600-3000 MET x minutes or 150-750 minutes per week) and high physical activity (> 3000 MET x minutes or > 750 minutes per week) were associated with graded reduction in mortality (hazard ratio 0.80, 95% CI 0.74-0.87 and 0.65, 0.60-0.71, p< 0.0001 for trend), and major CVD (0.86, 0.78-0.93, p< 0.001 for trend). Higher physical activity was associated with lower risk of CVD and mortality in high-income, middle-income, and low-income countries. The adjusted population attributable fraction for not meeting the physical activity guidelines was 8.0% for mortality and 4.6% for major CVD, and for not meeting high physical activity was 13.0% for mortality and 9.5% for major CVD. Both recreational and non-recreational physical activity were associated with benefits. Interpretation Higher recreational and non-recreational physical activity was associated with a lower risk of mortality and CVD events in individuals from low-income, middle-income, and high-income countries. Increasing physical activity is a simple, widely applicable, low cost global strategy that could reduce deaths and CVD in middle age.

Artículo original

Population Health Research Institute, the Canadian Institutes of Health Research, Heart and Stroke Foundation of Ontario, Ontario SPOR Support Unit, Ontario Ministry of Health and Long-Term Care, AstraZeneca, Sanofi-Aventis, Boehringer Ingelheim, Servier, GSK, Novartis, King Pharma, and national and local organisations in participating countries that are listed at the end of the Article.

Instituto de Investigación en Salud Poblacional, Institutos Canadienses de Investigación en Salud, Fundación de Corazón y Accidentes Cerebrovasculares de Ontario, Unidad de Apoyo SPOR de Ontario, Ministerio de Salud y Cuidados a Largo Plazo de Ontario, AstraZeneca, Sanofi-Aventis, Boehringer Ingelheim, Servier, GSK, Novartis, King Pharma y organizaciones nacionales y locales en los países participantes que se enumeran al final del artículo.

10.1016/S0140-6736(17)31634-3

pdf

http://dx.doi.org/10.1016/S0140-6736(17)31634-3

Medicine, General & Internal

Sistema Cardiovascular y Cardiaco

Salud Pública y Ambiental

Ciencias del Deporte y Acondicionamiento Físico

WOS:000418101000025

The effect of physical activity on mortality and cardiovascular disease in 130 000 people from 17 high-income, middle-income, and low-income countries: the PURE study

Artículo original

version publicada

ELSEVIER SCIENCE INC

LANCET

Medicina general e interna

0140-6736

en

Population Health Research Institute#Canadian Institutes of Health Research#Heart and Stroke Foundation#Ontario SPOR Support Unit#Ontario Ministry of Health and Long-Term Care#AstraZeneca#Sanofi-Aventis#Boehringer Ingelheim#Servier#GSK#Novartis#King Pharma

PHRI

CIHR

Ministry of Health and Long Term Care (CANADA)

Heart and Stroke

ERC

Ministry of Health and Long-Term Care

AstraZeneca

Sanofi-Aventis

Boehringer Ingelheim

Servier

GSK

Novartis

King Pharma

Population Health Research Institute, the Canadian Institutes of Health Research, Heart and Stroke Foundation of Ontario, Ontario SPOR Support Unit, Ontario Ministry of Health and Long-Term Care, AstraZeneca, Sanofi-Aventis, Boehringer Ingelheim, Servier, GSK, Novartis, King Pharma, and national and local organisations in participating countries that are listed at the end of the Article.

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