Design of dipalmitoyl lecithin liposomes loaded with quercetin and rutin and their release kinetics from carboxymethyl cellulose edible films

Primer Autor
Silva-Weiss, A.
Co-autores
Quilaqueo, M.#Venegas, O.#Ahumada, M.#Silva, W.#Osorio, F.#Gimenez, B.
Título
Design of dipalmitoyl lecithin liposomes loaded with quercetin and rutin and their release kinetics from carboxymethyl cellulose edible films
Editorial
ELSEVIER SCI LTD
Revista
JOURNAL OF FOOD ENGINEERING
Lenguaje
en
Resumen
Quercetin and rutin were encapsulated in liposomes based on dipalmitoyl lecithin. The effect ofliposomal formulation stage for flavonol incorporation and the size-reducing method on encapsulation efficiency (EE) of flavonols and physical properties of liposomes were evaluated. In addition, the release mechanism and kinetics of polyphenols from carboxymethyl cellulose edible films were studied through modeling and simulation equations. When flavonols were incorporated during the phospholipid film formation stage, low polydispersity index (0.32 and 0.20) and high EE (88.9 and 74.1%) of quercetin and rutin, respectively, were obtained. Sonication gave liposomes with higher zeta potential (36.9-42.4 mV) than extrusion (13.3-17.1 mV), and quercetin-loaded liposomes were the most stable during 21 days of storage. In CMC films, diffusion coefficients of flavonols were higher for non-encapsulated flavonols than encapsulated flavonols. The release of non-encapsulated quercetin and rutin from CMC films was 25% and 24% higher than in the case of encapsulated quercetin and rutin at day 21. The released mechanism agreed with Fickian diffusion for encapsulated and non-encapsulated quercetin, whereas the release mechanism of encapsulated and non-encapsulated rutin agreed with non-Fickian diffusion. These results highlight the relevance of using liposomes as encapsulation technology, able to preserve polyphenols and control their release in the design of edible films with antioxidant activity for improving food shelf life. (C) 2018 Elsevier Ltd. All rights reserved.
Tipo de Recurso
Artículo original
Description
This work was financially supported by The National Fund for Scientific and Technological Development, FONDECYT project No. 11140509 (CONICYT - Chile) and DICYT-USACH.
Este trabajo fue financiado por el Fondo Nacional de Desarrollo Científico y Tecnológico, proyecto FONDECYT N° 11140509 (CONICYT - Chile) y DICYT-USACH.
doi
10.1016/j.jfoodeng.2018.01.001
Formato Recurso
pdf
Palabras Claves
Controlled release# Encapsulation# Edible film# Flavonol# Physical stability
Ubicación del archivo
http://dx.doi.org/10.1016/j.jfoodeng.2018.01.001
Categoría OCDE
Engineering, Chemical# Food Science & Technology
Materias
Liberación controlada# Encapsulación# Película comestible# flavonol# Estabilidad física
Disciplinas de la OCDE
Biotecnología Alimentaria
Tecnología de los Alimentos
Bioquímica
Id de Web of Science
WOS:000424718600019
Título de la cita (Recomendado-único)
Design of dipalmitoyl lecithin liposomes loaded with quercetin and rutin and their release kinetics from carboxymethyl cellulose edible films
Identificador del recurso (Mandatado-único)
Artículo original
Versión del recurso (Recomendado-único)
version publicada
Editorial
ELSEVIER SCI LTD
Revista/Libro
JOURNAL OF FOOD ENGINEERING
Categoría WOS
Ingeniería Química# Ciencia y tecnología de los alimentos
ISSN
0260-8774
Idioma
en
Referencia del Financiador (Mandatado si es aplicable-repetible)
ANID FONDECYT 11140509
USACH DICYT
Descripción
This work was financially supported by The National Fund for Scientific and Technological Development, FONDECYT project No. 11140509 (CONICYT - Chile) and DICYT-USACH.
Formato
pdf
Tipo de ruta
hibrida#verde
Access Rights
metadata
Derechos de acceso
metadata
Página de inicio (Recomendado-único)
1259
Página final (Recomendado-único)
1267
Colecciones
Colección Publicaciones Científicas
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