Repositorio
Institucional

Botto, Alberto

Jimenez, Juan P.#Herrera, Luisa#Leighton, Caroline#Rossi, Jose L.#Quevedo, Yamil#Silva, Jaime R.#Martinez, Felipe#Assar, Rodrigo#Salazar, Luis A.#Ortiz, Manuel#Rios, Ulises#Barros, Paulina#Jaramillo, Karina#Luyten, Patrick

Psychotherapy and Genetic Neuroscience: An Emerging Dialog

FRONTIERS MEDIA SA

FRONTIERS IN GENETICS

en

"Recent research in psychiatric genetics has led to a move away from simple diathesis-stress models to more complex models of psychopathology incorporating a focus on gene-environment interactions and epigenetics. Our increased understanding of the way biology encodes the impact of life events on organisms has also generated more sophisticated theoretical models concerning the molecular processes at the interface between ""nature"" and ""nurture."" There is also increasing consensus that psychotherapy entails a specific type of learning in the context of an emotional relationship (i.e., the therapeutic relationship) that may also lead to epigenetic modifications across different therapeutic treatment modalities. This paper provides a systematic review of this emerging body of research. It is concluded that, although the evidence is still limited at this stage, extant research does indeed suggest that psychotherapy may be associated with epigenetic changes. Furthermore, it is argued that epigenetic studies may play a key role in the identification of biomarkers implicated in vulnerability for psychopathology, and thus may improve diagnosis and open up future research opportunities regarding the mechanism of action of psychotropic drugs as well as psychotherapy. We review evidence suggesting there may be important individual differences in susceptibility to environmental input, including psychotherapy. In addition, given that there is increasing evidence for the transgenerational transmission of epigenetic modifications in animals and humans exposed to trauma and adversity, epigenetic changes produced by psychotherapy may also potentially be passed on to the next generation, which opens up new perspective for prevention science. We conclude this paper stressing the limitations of current research and by proposing a set of recommendations for future research in this area."

Artículo de revisión

This study was supported by CONICYT (National Fund for Research and Technology), FONDECYT Project No 1150166, and Grant No PII20150035, with co-funding of the Fund for Innovation and Competitiveness (FIC) of the Chilean Ministry of Economy, Development and Tourism, through the Millennium Scientific Initiative, Grant No IS130005. Also, this project received funding from the Scientific Cooperation Program with Latin American Universities (Universidad de Chile) and KU Leuven, 2012-2013.

Este estudio contó con el apoyo de CONICYT (Fondo Nacional de Investigación y Tecnología), Proyecto FONDECYT n.° 1150166 y Subvención n.° PII20150035, con cofinanciamiento del Fondo para la Innovación y la Competitividad (FIC) del Ministerio de Economía, Fomento y Turismo de Chile, a través de la Iniciativa Científica Milenio, Subvención n.° IS130005. Asimismo, este proyecto recibió financiación del Programa de Cooperación Científica con Universidades Latinoamericanas (Universidad de Chile) y la Universidad Católica de Lovaina (KU Leuven) en el período 2012-2013.

10.3389/fgene.2018.00257

pdf

gene-environment interactions# epigenetic modifications# subjective experience# psychopathology# psychotherapeutic change

http://dx.doi.org/10.3389/fgene.2018.00257

Genetics & Heredity

interacciones gen-ambiente# modificaciones epigenéticas# experiencia subjetiva# psicopatología# cambio psicoterapéutico

Psiquiatría

Genética y Herencia

Otras Especialidades de la Psicología

WOS:000438979700001

Psychotherapy and Genetic Neuroscience: An Emerging Dialog

Artículo de revisión

version publicada

FRONTIERS MEDIA SA

FRONTIERS IN GENETICS

Genética y herencia

en

ANID FONDECYT 1150166, and Grant No PII20150035

ANID CONICYT FONDECYT 1150166

ANID CONICYT FONDECYT PII20150035

Ministerio de Economía, Desarrollo y Turismo Millennium Scientific Initiative IS130005

UdeChile Scientific Cooperation Program with Latin American Universities

KU Leuven

This study was supported by CONICYT (National Fund for Research and Technology), FONDECYT Project No 1150166, and Grant No PII20150035, with co-funding of the Fund for Innovation and Competitiveness (FIC) of the Chilean Ministry of Economy, Development and Tourism, through the Millennium Scientific Initiative, Grant No IS130005. Also, this project received funding from the Scientific Cooperation Program with Latin American Universities (Universidad de Chile) and KU Leuven, 2012-2013.

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