Gender-Specific Association Between ABCC2-24C&gt,T SNP and Reduction in Triglycerides in Chilean Patients Treated With Atorvastatin

Primer Autor
Salazar, Luis A.
Co-autores
Prado, Yalena#Arencibia, Alberto#Zambrano, Tomas
Título
Gender-Specific Association Between ABCC2-24C&gt,T SNP and Reduction in Triglycerides in Chilean Patients Treated With Atorvastatin
Editorial
WILEY
Revista
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Lenguaje
en
Resumen
Statins are the first-line therapy prescribed to lower plasma cholesterol levels. Although being safe and showing several beneficial cholesterol-independent pleiotropic effects, a significant variability regarding statin's therapeutic goals has been abundantly documented, but less understood. We aimed to investigate the influence of the ABCC2 -24C>T single nucleotide polymorphism on Chilean hypercholesterolaemic individuals treated for 4 weeks with 10 mg/day atorvastatin. A total of 127 individuals medicated with atorvastatin 10 mg/day/4 weeks were included. Lipid profiles were determined before and after drug administration by conventional assays. Genotyping of the ABCC2 rs717620 SNP (-24C>T) was performed with TaqMan((R)) Drug Metabolism Genotyping Assays. As expected, atorvastatin reduced TC, LDL-C and TG concentrations (p < 0.05). Also, HDL-C levels were increased (p < 0.05). Minor allele frequency for the rs717620 was 0.232. Overall, atorvastatin response was not associated with the ABCC2 rs717620 SNP (p > 0.05). Nonetheless, in male individuals carrying the -24T allele, we observed an attenuated reduction in both TG values and the TG/HDL-C ratio after 10 mg/day atorvastatin. This study indicates that TG levels and the TG/HDL-C ratio are affected by the rs717620 SNP in Chilean males but not female individuals after atorvastatin treatment.
Tipo de Recurso
Artículo original
Description
This work was supported by grants from Fondecyt-Chile (Grant No. 1171765). Yalena Prado is the current recipient of a fellowship from Conicyt, Chile. Tomas Zambrano is a Postdoctoral Research Fellow at Universidad de La Frontera, Temuco, Chile. We thank Alexy Rosales for selecting patients to execute this investigation.
Este trabajo fue financiado con becas de Fondecyt-Chile (Beca n.° 1171765). Yalena Prado es beneficiaria de una beca de Conicyt, Chile. Tomás Zambrano es investigador postdoctoral en la Universidad de La Frontera, Temuco, Chile. Agradecemos a Alexy Rosales por seleccionar a los pacientes para realizar esta investigación.
doi
10.1111/bcpt.12943
Formato Recurso
pdf
Ubicación del archivo
http://dx.doi.org/10.1111/bcpt.12943
Categoría OCDE
Pharmacology & Pharmacy# Toxicology
Disciplinas de la OCDE
Farmacología y Farmacia
Genética Humana
Endocrinología y Metabolismo
Id de Web of Science
WOS:000430166600008
Título de la cita (Recomendado-único)
Gender-Specific Association Between <i>ABCC2</i>-24C&gt,T SNP and Reduction in Triglycerides in Chilean Patients Treated With Atorvastatin
Identificador del recurso (Mandatado-único)
Artículo original
Versión del recurso (Recomendado-único)
version publicada
Editorial
WILEY
Revista/Libro
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Categoría WOS
Farmacología y Farmacia# Toxicología
ISSN
1742-7835
Idioma
en
Referencia del Financiador (Mandatado si es aplicable-repetible)
ANID FONDECYT 117176#
ANID FONDECYT 1171765
UFRO
Descripción
This work was supported by grants from Fondecyt-Chile (Grant No. 1171765). Yalena Prado is the current recipient of a fellowship from Conicyt, Chile. Tomas Zambrano is a Postdoctoral Research Fellow at Universidad de La Frontera, Temuco, Chile. We thank Alexy Rosales for selecting patients to execute this investigation.
Formato
pdf
Tipo de ruta
hibrida
Access Rights
acceso abierto
Derechos de acceso
acceso abierto
Página de inicio (Recomendado-único)
1254
Página final (Recomendado-único)
1260
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