Repositorio
Institucional

Salazar, Luis A.

Prado, Y.#Zambrano, T.

Transporter genes ABCG2 rs2231142 and ABCB1 rs1128503 polymorphisms and atorvastatin response in Chilean subjects

WILEY

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

en

What is known and objectiveStatins are first-line therapy for reducing high cholesterol levels. However, response to these drugs shows high interindividual variability. We aimed to investigate the influence of two single nucleotide polymorphisms (SNP) (ABCB1 rs1128503 and ABCG2 rs2231142) in the ABC transporter genes on response to short-term low-dose atorvastatin in Chilean hypercholesterolaemic patients. MethodsWe studied 127 Chilean hypercholesterolaemic patients treated with 10mg/d atorvastatin for 4weeks. The lipid profile was determined before and after drug administration. Genotyping of the rs1128503 and rs2231142 variants was performed using TaqMan((R)) Drug Metabolism Genotyping Assays. Results and discussionGenotype distribution for all polymorphisms investigated was consistent with the Hardy-Weinberg equilibrium. Atorvastatin reduced TC, LDL-C and TG concentrations (P<.05), whereas HDL-C levels were found to be increased (P<.05). Minor allele frequencies for rs1128503 and rs2231142 variants were 0.453 and 0.075, respectively. In this study, patients prescribed with short-term low-dose atorvastatin and carrying ABCB1 (rs1128503) or ABCG2 (rs2231142) SNPs did not show differences in LDL-C response (P>.05). What is new and conclusionThe ABCB1 SNP was not associated with response to atorvastatin in Chilean subjects. The few ABCG2 421A homozygotes did not allow meaningful inferences to be made for this polymorphism.

Artículo original

This study was supported by grants from Fondecyt, Chile (1130675). Yalena Prado is the current recipient of a fellowship from Conicyt, Chile. Tomas Zambrano is a Postdoctoral Research Fellow at Universidad de La Frontera, Temuco, Chile.

Este estudio fue financiado con fondos de Fondecyt, Chile (1130675). Yalena Prado es actualmente beneficiaria de una beca de Conicyt, Chile. Tomás Zambrano es investigador postdoctoral en la Universidad de La Frontera, Temuco, Chile.

10.1111/jcpt.12607

pdf

pharmacogenetics# polymorphism# statin

http://dx.doi.org/10.1111/jcpt.12607

Pharmacology & Pharmacy

farmacogenética# polimorfismo# estatina

Farmacología y Farmacia

Genética Humana

Medicina General e Interna

WOS:000419095800013

Transporter genes <i>ABCG2</i> rs2231142 and <i>ABCB1</i> rs1128503 polymorphisms and atorvastatin response in Chilean subjects

Artículo original

version publicada

WILEY

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Farmacología y farmacia

0269-4727

en

ANID FONDECYT 1130675

This study was supported by grants from Fondecyt, Chile (1130675). Yalena Prado is the current recipient of a fellowship from Conicyt, Chile. Tomas Zambrano is a Postdoctoral Research Fellow at Universidad de La Frontera, Temuco, Chile.

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