Transporter genes ABCG2 rs2231142 and ABCB1 rs1128503 polymorphisms and atorvastatin response in Chilean subjects

Primer Autor
Salazar, Luis A.
Co-autores
Prado, Y.#Zambrano, T.
Título
Transporter genes ABCG2 rs2231142 and ABCB1 rs1128503 polymorphisms and atorvastatin response in Chilean subjects
Editorial
WILEY
Revista
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
Lenguaje
en
Resumen
What is known and objectiveStatins are first-line therapy for reducing high cholesterol levels. However, response to these drugs shows high interindividual variability. We aimed to investigate the influence of two single nucleotide polymorphisms (SNP) (ABCB1 rs1128503 and ABCG2 rs2231142) in the ABC transporter genes on response to short-term low-dose atorvastatin in Chilean hypercholesterolaemic patients. MethodsWe studied 127 Chilean hypercholesterolaemic patients treated with 10mg/d atorvastatin for 4weeks. The lipid profile was determined before and after drug administration. Genotyping of the rs1128503 and rs2231142 variants was performed using TaqMan((R)) Drug Metabolism Genotyping Assays. Results and discussionGenotype distribution for all polymorphisms investigated was consistent with the Hardy-Weinberg equilibrium. Atorvastatin reduced TC, LDL-C and TG concentrations (P<.05), whereas HDL-C levels were found to be increased (P<.05). Minor allele frequencies for rs1128503 and rs2231142 variants were 0.453 and 0.075, respectively. In this study, patients prescribed with short-term low-dose atorvastatin and carrying ABCB1 (rs1128503) or ABCG2 (rs2231142) SNPs did not show differences in LDL-C response (P>.05). What is new and conclusionThe ABCB1 SNP was not associated with response to atorvastatin in Chilean subjects. The few ABCG2 421A homozygotes did not allow meaningful inferences to be made for this polymorphism.
Tipo de Recurso
Artículo original
Description
This study was supported by grants from Fondecyt, Chile (1130675). Yalena Prado is the current recipient of a fellowship from Conicyt, Chile. Tomas Zambrano is a Postdoctoral Research Fellow at Universidad de La Frontera, Temuco, Chile.
Este estudio fue financiado con fondos de Fondecyt, Chile (1130675). Yalena Prado es actualmente beneficiaria de una beca de Conicyt, Chile. Tomás Zambrano es investigador postdoctoral en la Universidad de La Frontera, Temuco, Chile.
doi
10.1111/jcpt.12607
Formato Recurso
pdf
Palabras Claves
pharmacogenetics# polymorphism# statin
Ubicación del archivo
http://dx.doi.org/10.1111/jcpt.12607
Categoría OCDE
Pharmacology & Pharmacy
Materias
farmacogenética# polimorfismo# estatina
Disciplinas de la OCDE
Farmacología y Farmacia
Genética Humana
Medicina General e Interna
Id de Web of Science
WOS:000419095800013
Título de la cita (Recomendado-único)
Transporter genes <i>ABCG2</i> rs2231142 and <i>ABCB1</i> rs1128503 polymorphisms and atorvastatin response in Chilean subjects
Identificador del recurso (Mandatado-único)
Artículo original
Versión del recurso (Recomendado-único)
version publicada
Editorial
WILEY
Revista/Libro
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
Categoría WOS
Farmacología y farmacia
ISSN
0269-4727
Idioma
en
Referencia del Financiador (Mandatado si es aplicable-repetible)
ANID FONDECYT 1130675
Descripción
This study was supported by grants from Fondecyt, Chile (1130675). Yalena Prado is the current recipient of a fellowship from Conicyt, Chile. Tomas Zambrano is a Postdoctoral Research Fellow at Universidad de La Frontera, Temuco, Chile.
Formato
pdf
Tipo de ruta
hibrida
Access Rights
metadata
Derechos de acceso
metadata
Página de inicio (Recomendado-único)
255
Página final (Recomendado-único)
272
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