Repositorio
Institucional

Quintanilla, Maria Elena

Quiroz, Gabriel#Guerra-Diaz, Nicolas#Iturriaga-Vasquez, Patricio#Rivera-Meza, Mario#Sotomayor-Zarate, Ramon

Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors, decreases ethanol consumption in alcohol-preferring UChB rats

ELSEVIER SCIENCE BV

BEHAVIOURAL BRAIN RESEARCH

en

Alcohol abuse is a worldwide health problem with high economic costs to health systems. Emerging evidence suggests that modulation of brain nicotinic acetylcholine receptors (nAChRs) may be a therapeutic target for alcohol dependence. In this work, we assess the effectiveness of four doses of erysodine (1.5, 2.0, 4.0 or 8.0 mg/kg/day, i.p.), a competitive antagonist of nAChRs, on voluntary ethanol consumption behavior in alcohol-preferring UChB rats, administered during three consecutive days. Results show that erysodine administration produces a dose-dependent reduction in ethanol consumption respect to saline injection (control group). The highest doses of erysodine (4 and 8 mg/kg) reduce (45 and 66%, respectively) the ethanol intake during treatment period and first day of post-treatment compared to control group. While, the lowest doses of erysodine (1.5 and 2 mg/kg) only reduce ethanol intake during one day of treatment period. These effective reductions in ethanol intake were 23 and 29% for 1.5 and 2 mg/kg erysodine, respectively. Locomotor activity induced by a high dose of erysodine (10 mg/kg) was similar to those observed with saline injection in control rats, showing that the reduction in ethanol intake was not produced by hypolocomotor effect induced by erysodine. This is the first report showing that erysodine reduces ethanol intake in UChB rats in a dose-dependent manner. Our results highlight the role of nAChRs in the reward effects of ethanol and its modulation as a potentially effective pharmacological alternative for alcohol dependence treatment.

Artículo original

"We thank Dr. Isabel Bermudez (Oxford Brookes University, UK) for critical reading of the manuscript. This work was supported by ""Fondo Nacional de Desarrollo Cientifico y Tecnologico"" (FONDECYT) Grants No 113-0012 (M.E.Q.), No 115-0615 (P.I-V.) and No 116-0398 (R.S-Z.). G.Q. and N.G-D were fellows of CONICYT National Ph.D. Scholar Fellowship."

"Agradecemos a la Dra. Isabel Bermúdez (Universidad Oxford Brookes, Reino Unido) por la lectura crítica del manuscrito. Este trabajo contó con el apoyo del Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT), subvenciones n.º 113-0012 (M.E.Q.), n.º 115-0615 (P.I.-V.) y n.º 116-0398 (R.S.-Z.). G.Q. y N.G.D. fueron becarios de la Beca Nacional de Doctorado de CONICYT.

We thank Dr. Isabel Bermudez (Oxford Brookes University, UK) for critical reading of the manuscript. This work was supported by ""Fondo Nacional de Desarrollo Cientifico y Tecnologico"" (FONDECYT) Grants No 113-0012 (M.E.Q.), No 115-0615 (P.I-V.) and No 116-0398 (R.S-Z.). G.Q. and N.G-D were fellows of CONICYT National Ph.D. Scholar Fellowship."

10.1016/j.bbr.2018.04.038

pdf

Erysodine# Alcohol dependence# Ethanol# UChB rats# nAChRs antagonism# Voluntary ethanol drinking

http://dx.doi.org/10.1016/j.bbr.2018.04.038

Behavioral Sciences# Neurosciences

Erisodina# Dependencia del alcohol# Etanol# ratas UChB# antagonismo de las NAChR# Consumo voluntario de etanol

Farmacología y Farmacia

Abuso de Substancias

Neurociencias

WOS:000436220100023

Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors, decreases ethanol consumption in alcohol-preferring UChB rats

Artículo original

version publicada

ELSEVIER SCIENCE BV

BEHAVIOURAL BRAIN RESEARCH

Ciencias del Comportamiento# Neurociencias

0166-4328

en

Oxford Brookes University, UK#ANID FONDECYT 113-0012#ANID FONDECYT 115-0615#ANID FONDECYT 116-0398

ANID FONDECYT 113-0012

ANID FONDECYT 115-0615

ANID FONDECYT 116-0398

"We thank Dr. Isabel Bermudez (Oxford Brookes University, UK) for critical reading of the manuscript. This work was supported by ""Fondo Nacional de Desarrollo Cientifico y Tecnologico"" (FONDECYT) Grants No 113-0012 (M.E.Q.), No 115-0615 (P.I-V.) and No 116-0398 (R.S-Z.). G.Q. and N.G-D were fellows of CONICYT National Ph.D. Scholar Fellowship."

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