Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide

Primer Autor
Mattea, Facundo
Co-autores
Chacon, David#Strumia, Miriam#Valente, Mauro
Título
Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide
Editorial
PERGAMON-ELSEVIER SCIENCE LTD
Revista
RADIATION MEASUREMENTS
Lenguaje
en
Resumen
The use of additives in polymer gel dosimeters to enhance their sensitivity or to improve their performance is of great importance for their application in radiomedicine. Inorganic salts have been used as additives with this purpose, however, their presence in the dosimeters induce severe modifications in their mechanical properties and consequently in their capabilities to maintain a stable dose distribution with time. Most studies in this area conclude in the need to use chemical modifications of the species responsible for the mechanical properties of the dosimeters, which in most cases is a gelatin matrix. In this study, a covalent crosslinking of the gelatin matrix of PAGAT dosimeters doped with different inorganic salts, namely MgCl2, CaCl2 and MnCl2 has been carried out. The mechanical properties, X-ray sensitivity and dose distribution stability in these materials were compared to those of PAGAT. The results indicated a compromise between the crosslinking of the gelatin structure and the sensitivity of the dosimetric material. Therefore, the proper selection of the degree of crosslinking and the inorganic salt concentration must be considered. An enhanced dosimeter was obtained by adding MgCl2 with a 1M concentration and by crosslinking the gelatin matrix with glutaraldehyde at a 0.08% w/v concentration. This material presented a 75% enhanced sensitivity relative to PAGAT and similar temporal stability and spatial stability in 2D dose distributions.
Tipo de Recurso
Artículo original
Description
This study was partially financed by CONICET by means of the Project ESPORA IePIP 112-20130100658CO, PIP 112-0.20110101029 and SeCyT-UNC by means of DOSCOM I project and INSPIRATE I program. This project was also partially supported by Universidad de La Frontera by DIUFRO DI6008-16 and DI1003-17 projects. The authors would also like to thank to Universidad Nacional (UNA), Heredia, Costa Rica for the financial support (JB-C 0612-2014) of the PhD studies of D. Chacon.
Este estudio fue financiado parcialmente por el CONICET mediante los proyectos ESPORA IePIP 112-20130100658CO, PIP 112-0.20110101029 y SeCyT-UNC mediante los proyectos DOSCOM I y INSPIRATE I. Este proyecto también fue financiado parcialmente por la Universidad de La Frontera mediante los proyectos DIUFRO DI6008-16 y DI1003-17. Los autores también agradecen a la Universidad Nacional (UNA), Heredia, Costa Rica, por el apoyo financiero (JB-C 0612-2014) para los estudios de doctorado de D. Chacón.
doi
10.1016/j.radmeas.2018.07.004
Formato Recurso
pdf
Palabras Claves
Inorganic salts# Polymer# Dosimetry# Acrylamide# Gelatin crosslinking
Ubicación del archivo
http://dx.doi.org/10.1016/j.radmeas.2018.07.004
Categoría OCDE
Nuclear Science & Technology
Materias
Sales inorgánicas# Polímero# dosimetría# acrilamida# Reticulación de gelatina
Disciplinas de la OCDE
Ingeniería Médica
Tecnología Médica
Polímeros
Id de Web of Science
WOS:000445983600002
Título de la cita (Recomendado-único)
Effect of inorganic salts and matrix crosslinking on the dose response of polymer gel dosimeters based on acrylamide
Identificador relacionado
hdl.handle.net/11336/91579
Identificador del recurso (Mandatado-único)
Artículo original
Versión del recurso (Recomendado-único)
version publicada
Editorial
PERGAMON-ELSEVIER SCIENCE LTD
Revista/Libro
RADIATION MEASUREMENTS
Categoría WOS
Ciencia y tecnología nucleares
ISSN
1350-4487
Idioma
en
Referencia del Financiador (Mandatado si es aplicable-repetible)
CONICET PIP 112-20130100658CO#CONICET PIP 112-0.20110101029#UFRO DI6008-16#UFRO DI1003-17#UNA B-C 0612-2014
CONICET ESPORA IePIP 112-20130100658CO
CONICET ESPORA PIP 112-0.20110101029
SeCyT UNC
UFRO DI6008-16
UFRO DI1003-17
Universidad Nacional (UNA), Heredia, Costa Rica JB-C 0612-2014
Descripción
This study was partially financed by CONICET by means of the Project ESPORA IePIP 112-20130100658CO, PIP 112-0.20110101029 and SeCyT-UNC by means of DOSCOM I project and INSPIRATE I program. This project was also partially supported by Universidad de La Frontera by DIUFRO DI6008-16 and DI1003-17 projects. The authors would also like to thank to Universidad Nacional (UNA), Heredia, Costa Rica for the financial support (JB-C 0612-2014) of the PhD studies of D. Chacon.
Formato
pdf
Tipo de ruta
hibrida#verde
Access Rights
metadata
Derechos de acceso
metadata
Página de inicio (Recomendado-único)
1
Página final (Recomendado-único)
8
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