Inspiratory Capacity and Polymorphism of Angiotensin Converter Enzyme in Young Chileans

Primer Autor
Munoz Cofre, Rodrigo
Co-autores
Munoz, Mariela#Conei, Daniel#del Sol, Mariano#Pacheco Valles, Alejandro
Título
Inspiratory Capacity and Polymorphism of Angiotensin Converter Enzyme in Young Chileans
Editorial
SOC CHILENA ANATOMIA
Revista
INTERNATIONAL JOURNAL OF MORPHOLOGY
Lenguaje
es
Resumen
The aim of the present research is to determine the inspiratory capacity (IC) in a group of sedentary Chilean university students grouped by the genotype (polymorphism rs4646994) of the angiotensin-converting enzyme (ACE) gene. Eighty three individuals (18 to 35 years old), 37 women and 46 men were selected through non-probabilistic sampling. The IC was measured through body plethysmograph, DNA was extracted from blood with EDTA and the polymerase chain reaction (PCR) was performed for the Ins / Del polymorphism of the ECA. Normality of the data was determined, using Student's t-test or ANOVA for the parametric variables, and in the non-parametric U-tests of Mann-Whitney or Kruskal-Wallis, a value of p<0.05 being considered significant. The distribution of genotypes was found in Hardy Weinberg equilibrium (X-2 = 1.872, p = 0.171 for men and X-2 = 3.424, p = 0.064 for women), the IC, in both sexes, showed no significant differences when compared by genotype. The men carrying the Ins / Ins genotype had higher IC levels in relation to the gentile group Del / Del - Ins / Del. Women with allelic dominance Ins had a higher IC than those belonging to the Del / Del group. There was a greater IC in female participants with allelic dominance Ins and masculine homozygous Ins, of the ACE gene.
Tipo de Recurso
Artículo original
doi
10.4067/S0717-95022018000301149
Formato Recurso
pdf
Palabras Claves
Inspiratory capacity# Angiotensin# converting enzyme# Sedentary
Ubicación del archivo
http://dx.doi.org/10.4067/S0717-95022018000301149
Categoría OCDE
Anatomy & Morphology
Materias
Capacidad inspiratoria# angiotensina# enzima convertidora# Sedentario
Disciplinas de la OCDE
Genética y Herencia
Biología Molecular
Fisiología
Id de Web of Science
WOS:000444099600059
Título de la cita (Recomendado-único)
Inspiratory Capacity and Polymorphism of Angiotensin Converter Enzyme in Young Chileans
Identificador del recurso (Mandatado-único)
Artículo original
Versión del recurso (Recomendado-único)
version publicada
Editorial
SOC CHILENA ANATOMIA
Revista/Libro
INTERNATIONAL JOURNAL OF MORPHOLOGY
Categoría WOS
Anatomía y Morfología
ISSN
0717-9502
Idioma
es
Formato
pdf
Tipo de ruta
dorada#verde
Access Rights
acceso abierto
Derechos de acceso
acceso abierto
License
CC BY-NC
Página de inicio (Recomendado-único)
185
Página final (Recomendado-único)
192
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