Repositorio
Institucional

Munoz Cofre, Rodrigo

Munoz, Mariela#Conei, Daniel#del Sol, Mariano#Pacheco Valles, Alejandro

Inspiratory Capacity and Polymorphism of Angiotensin Converter Enzyme in Young Chileans

SOC CHILENA ANATOMIA

INTERNATIONAL JOURNAL OF MORPHOLOGY

es

The aim of the present research is to determine the inspiratory capacity (IC) in a group of sedentary Chilean university students grouped by the genotype (polymorphism rs4646994) of the angiotensin-converting enzyme (ACE) gene. Eighty three individuals (18 to 35 years old), 37 women and 46 men were selected through non-probabilistic sampling. The IC was measured through body plethysmograph, DNA was extracted from blood with EDTA and the polymerase chain reaction (PCR) was performed for the Ins / Del polymorphism of the ECA. Normality of the data was determined, using Student's t-test or ANOVA for the parametric variables, and in the non-parametric U-tests of Mann-Whitney or Kruskal-Wallis, a value of p<0.05 being considered significant. The distribution of genotypes was found in Hardy Weinberg equilibrium (X-2 = 1.872, p = 0.171 for men and X-2 = 3.424, p = 0.064 for women), the IC, in both sexes, showed no significant differences when compared by genotype. The men carrying the Ins / Ins genotype had higher IC levels in relation to the gentile group Del / Del - Ins / Del. Women with allelic dominance Ins had a higher IC than those belonging to the Del / Del group. There was a greater IC in female participants with allelic dominance Ins and masculine homozygous Ins, of the ACE gene.

Artículo original

10.4067/S0717-95022018000301149

pdf

Inspiratory capacity# Angiotensin# converting enzyme# Sedentary

http://dx.doi.org/10.4067/S0717-95022018000301149

Anatomy & Morphology

Capacidad inspiratoria# angiotensina# enzima convertidora# Sedentario

Genética y Herencia

Biología Molecular

Fisiología

WOS:000444099600059

Inspiratory Capacity and Polymorphism of Angiotensin Converter Enzyme in Young Chileans

Artículo original

version publicada

SOC CHILENA ANATOMIA

INTERNATIONAL JOURNAL OF MORPHOLOGY

Anatomía y Morfología

0717-9502

es

pdf

dorada#verde

acceso abierto

acceso abierto

CC BY-NC

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