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CBCT Analysis of Rabbit Temporomandibular Joints With Osteoarthrosis Induced by Monoiodoacetate and Papain

Primer Autor	Alves, Nilton
Co-autores	Garay, Ivonne#Deana, Naira#Molinett, Marcia
Título	CBCT Analysis of Rabbit Temporomandibular Joints With Osteoarthrosis Induced by Monoiodoacetate and Papain
Editorial	SOC CHILENA ANATOMIA
Revista	INTERNATIONAL JOURNAL OF MORPHOLOGY
Lenguaje	en
Resumen	Osteoarthrosis (OA) is a degenerative disease characterized by loss of joint cartilage, remodelling of the subchondral bone, narrowing of joint spaces and the formation of osteophytes. Animal models are used to study the mechanisms of OA, as well as to test the effects of anti-osteoarthrosis drugs. The objective of the present study was to determine the changes identifiable bv imaging techniques occurring in rabbit temporomandibular joints (TMJ) at 15, 25 and 45 days after OA inducement by monoiodoacetate (MIA) and papain. The imaging technology used was cone-beam computerised tomography (CBCT). The model animals were 22 young adult male New Zealand rabbits, divided randomly into three study groups: Four rabbits in the control group, nine in the papain experimental group and nine in the monoiodoacetate (MIA) experimental group. OA was induced by arthrocentesis in the lower compartment of both TMJs. The rabbits were examined by CBCT at 15, 25 and 45 days after the injection of MIA and papain. The mandibular condyles presented loss of their rounded shape, deformation of the condyle or mandibular fossa, cortical irregularity, cortical wear and changes in the dimensions of the condyle. OA induction by MIA and papain generates changes observable by CBCT in the dimensions of the mandibular condyle in rabbits. Both inducers promote signs compatible with OA on the joint surfaces of the TMJ, MIA promotes more expressive changes.
Tipo de Recurso	Artículo original
Description	Universidad de La Frontera, Direccion de Investigacion, Proyecto DI16-0046 Universidad de La Frontera, Dirección de Investigación, Proyecto DI16-0046
doi	10.4067/S0717-95022018000200513
Formato Recurso	pdf
Palabras Claves	Induced osteoarthrosis# Cone-beam computerized tomography# Monoiodoacetate# Papain# Temporomandibular joint
Ubicación del archivo	http://dx.doi.org/10.4067/S0717-95022018000200513
Categoría OCDE	Anatomy & Morphology
Materias	Osteoartrosis inducida# Tomografía computarizada de haz cónico# monoyodoacetato# Papaína# articulación temporomandibular
Disciplinas de la OCDE	Odontología, Cirugía y Medicina Oral Otros Temas de Medicina Básica Tecnología Médica
Versión del recurso (Recomendado-único)	version publicada
Tipo de ruta	dorada verde
Access Rights	acceso abierto
Derechos de acceso	acceso abierto
Id de Web of Science	WOS:000438815300023
Título de la cita (Recomendado-único)	CBCT Analysis of Rabbit Temporomandibular Joints With Osteoarthrosis Induced by Monoiodoacetate and Papain
Identificador del recurso (Mandatado-único)	Artículo original
Editorial	SOC CHILENA ANATOMIA
Revista/Libro	INTERNATIONAL JOURNAL OF MORPHOLOGY
Categoría WOS	Anatomía y Morfología
ISSN	0717-9502
Idioma	en
Referencia del Financiador (Mandatado si es aplicable-repetible)	UFRO DI16-0010 UFRO DI16-0046
Descripción	Universidad de La Frontera, Direccion de Investigacion, Proyecto DI16-0046
Formato	pdf
License	CC BY-NC
Página de inicio (Recomendado-único)	331
Página final (Recomendado-único)	341