Repositorio UFRO · Omeka S

Role of Alcohol Consumption and Antioxidants on Global Methylation of DNA and Cancer

Primer Autor	del Sol, Mariano
Co-autores	Sandoval, Cristian#Vasquez, Belgica#Souza-Mello, Vanessa#Alberto Mandarim-de-Lacerda, Carlos
Título	Role of Alcohol Consumption and Antioxidants on Global Methylation of DNA and Cancer
Editorial	SOC CHILENA ANATOMIA
Revista	INTERNATIONAL JOURNAL OF MORPHOLOGY
Lenguaje	es
Resumen	Alcoholism is a chronic relapsing disease associated with psychological, social and physical dysfunction. Alcohol is not only an addictive substance, it also alters action and function of multiple systems and owns. Currently, several studies show that the environment can modulate gene expression of DNA by epigenetic mechanisms, thereby suggesting that alcohol consumption is a factor that can alter epigenetic patterns and therefore, the levels of gene expression. DNA methylation is an epigenetic process, that is a part of gene expression regulation preventing binding of transcription factors and encouraging the closed structure of chromatin. In this sense, changes in DNA methylation are recognized as one of the most common forms of molecular alteration in alcohol dependence and human neoplastic processes. Alcohol can be an important factor in activating the cancer by increasing the expression of certain oncogenes or repressing the ability of cells to repair DNA, which increases the likelihood of oncogenic mutations. However, the exact mechanisms of the pathogenesis of cancer linked to alcohol consumption remain unclear. Therefore, the objective of this review was to describe the mechanisms of DNA methylation and its relation to alcohol consumption and cancer.
Tipo de Recurso	Artículo original
doi	10.4067/S0717-95022018000100367
Formato Recurso	pdf
Palabras Claves	Epigenetics# Global methylation# DNA# Alcohol
Ubicación del archivo	http://dx.doi.org/10.4067/S0717-95022018000100367
Categoría OCDE	Anatomy & Morphology
Materias	Epigenética# Metilación global# ADN# Alcohol
Disciplinas de la OCDE	Biología Molecular Oncología Genética y Herencia
Id de Web of Science	WOS:000438813400058
Título de la cita (Recomendado-único)	Role of Alcohol Consumption and Antioxidants on Global Methylation of DNA and Cancer
Identificador del recurso (Mandatado-único)	Artículo original
Versión del recurso (Recomendado-único)	version publicada
Editorial	SOC CHILENA ANATOMIA
Revista/Libro	INTERNATIONAL JOURNAL OF MORPHOLOGY
Categoría WOS	Anatomía y Morfología
ISSN	0717-9502
Idioma	es
Formato	pdf
Tipo de ruta	dorada#verde
Access Rights	acceso abierto
Derechos de acceso	acceso abierto
License	CC BY-NC
Página de inicio (Recomendado-único)	487
Página final (Recomendado-único)	498