Role of Alcohol Consumption and Antioxidants on Global Methylation of DNA and Cancer

Primer Autor
del Sol, Mariano
Co-autores
Sandoval, Cristian#Vasquez, Belgica#Souza-Mello, Vanessa#Alberto Mandarim-de-Lacerda, Carlos
Título
Role of Alcohol Consumption and Antioxidants on Global Methylation of DNA and Cancer
Editorial
SOC CHILENA ANATOMIA
Revista
INTERNATIONAL JOURNAL OF MORPHOLOGY
Lenguaje
es
Resumen
Alcoholism is a chronic relapsing disease associated with psychological, social and physical dysfunction. Alcohol is not only an addictive substance, it also alters action and function of multiple systems and owns. Currently, several studies show that the environment can modulate gene expression of DNA by epigenetic mechanisms, thereby suggesting that alcohol consumption is a factor that can alter epigenetic patterns and therefore, the levels of gene expression. DNA methylation is an epigenetic process, that is a part of gene expression regulation preventing binding of transcription factors and encouraging the closed structure of chromatin. In this sense, changes in DNA methylation are recognized as one of the most common forms of molecular alteration in alcohol dependence and human neoplastic processes. Alcohol can be an important factor in activating the cancer by increasing the expression of certain oncogenes or repressing the ability of cells to repair DNA, which increases the likelihood of oncogenic mutations. However, the exact mechanisms of the pathogenesis of cancer linked to alcohol consumption remain unclear. Therefore, the objective of this review was to describe the mechanisms of DNA methylation and its relation to alcohol consumption and cancer.
Tipo de Recurso
Artículo original
doi
10.4067/S0717-95022018000100367
Formato Recurso
pdf
Palabras Claves
Epigenetics# Global methylation# DNA# Alcohol
Ubicación del archivo
http://dx.doi.org/10.4067/S0717-95022018000100367
Categoría OCDE
Anatomy & Morphology
Materias
Epigenética# Metilación global# ADN# Alcohol
Disciplinas de la OCDE
Biología Molecular
Oncología
Genética y Herencia
Id de Web of Science
WOS:000438813400058
Título de la cita (Recomendado-único)
Role of Alcohol Consumption and Antioxidants on Global Methylation of DNA and Cancer
Identificador del recurso (Mandatado-único)
Artículo original
Versión del recurso (Recomendado-único)
version publicada
Editorial
SOC CHILENA ANATOMIA
Revista/Libro
INTERNATIONAL JOURNAL OF MORPHOLOGY
Categoría WOS
Anatomía y Morfología
ISSN
0717-9502
Idioma
es
Formato
pdf
Tipo de ruta
dorada#verde
Access Rights
acceso abierto
Derechos de acceso
acceso abierto
License
CC BY-NC
Página de inicio (Recomendado-único)
487
Página final (Recomendado-único)
498
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