Epithelial-Mesenchymal Transitions in the Development of Testis

Primer Autor
Rojas, Mariana
Co-autores
Conei, Daniel#Bustos-Obregon, Eduardo
Título
Epithelial-Mesenchymal Transitions in the Development of Testis
Editorial
SOC CHILENA ANATOMIA
Revista
INTERNATIONAL JOURNAL OF MORPHOLOGY
Lenguaje
es
Resumen
Spermatogenesis is a continuous process which starts during the embryo-fetal development. Auto, para and juxtacrine relations indicate the interdependence of the interstitial cells (Leydig) with the peritubular cells (lamina propria) and sustentacular cells (Sertoli). Certain morphogens are fundamental in this process. Sustentacular cells are able to regulate differentiation and function and peritubular interstitial cells through production of IGF1, TGFA, TGFB and DHH. Peritubular cells are able to produce P-Mod-S regulating differentiation sustentacular cells and through FGF2 and FGF9 modulate epithelial-mesenchymal transitions between sustentacular cells and mesonephros. They also remodel the basal membrane of the testicular condom and regulate the differentiation and function of the interstitial cells by means of IGF1, TGFA and TGFB. Interstitial cells are responsible for the production of testosterone and INSL3, influencing male sexual differentiation. It is suggested that they come from mesenchymal cells of the coelomic epithelium and mesonephros. However, other authors propose their origin from cells of the neural crest. These influence through paracrine mechanisms proliferation sutentaculares cells by activin A, resulting in the expansion of cord testicular. The interactions between the different cell populations through morphogens induce a fundamental epithelial-mesenchymal transition in the formation and differentiation of the male gonad.
Tipo de Recurso
Artículo original
doi
10.4067/S0717-95022017000401444
Formato Recurso
pdf
Palabras Claves
Fetal testicle# Morphogen# Sustentacular cell# Peritubular cell# Interstitial cell
Ubicación del archivo
http://dx.doi.org/10.4067/S0717-95022017000401444
Categoría OCDE
Anatomy & Morphology
Materias
Testículo fetal# Morfógeno# Célula sustentacular# Célula peritubular# Célula intersticial
Disciplinas de la OCDE
Biología del Desarrollo
Biología Celular
Biología Reproductiva
Id de Web of Science
WOS:000428048400042
Título de la cita (Recomendado-único)
Epithelial-Mesenchymal Transitions in the Development of Testis
Identificador del recurso (Mandatado-único)
Artículo original
Versión del recurso (Recomendado-único)
version publicada
Editorial
SOC CHILENA ANATOMIA
Revista/Libro
INTERNATIONAL JOURNAL OF MORPHOLOGY
Categoría WOS
Anatomía y Morfología
ISSN
0717-9502
Idioma
es
Formato
pdf
Tipo de ruta
dorada#verde
Access Rights
acceso abierto
Derechos de acceso
acceso abierto
License
CC BY-NC
Página de inicio (Recomendado-único)
651
Página final (Recomendado-único)
663
Colecciones
Colección Publicaciones Científicas
Revisa las metricas alternativas de Almetrics
Revisa las citaciones de Dimensions