Repositorio
Institucional

Barrientos, Leticia

Troncoso, Claudia#Pavez, Monica#Santos, Andres#Salazar, Rodrigo

Structural and physiological implications of bacterial cell in antibiotic resistance mechanisms.

SOC CHILENA ANATOMIA

INTERNATIONAL JOURNAL OF MORPHOLOGY

es

The high adaptability of bacteria to hostile environments has favored antibacterial resistance development, impacting hospital and community healthcare worldwide. It has also affected disease control, limited therapeutic options and raised morbidity-mortality rate. This resistance ability is mediated by structural and physiological factors of bacteria acting at both extracellular and cellular levels. The ability of bacterial populations in biofilm formation and regulation of cellular signal quorum sensing at the extracellular level, allows for the evasion of antibiotic action. At a cellular level, the performance and behavior of the cell wall and cell membrane is emphasized, mainly by regulating the expression of inlet channels or porins and/or expulsion pumps preventing access to, or inducing the outflow of antibiotics. Other mechanisms integrate modification of drug activity by hydrolysis or modification of the active site of the drug. Further into intracellular level, bacteria can change the oxidation/reduction processes, modify the target sites of the antibiotic and inactivate transfer groups. Bacteria can also modify the ribosomal subunits affecting the antibiotics which inhibit protein synthesis, and cause modifications of gene expression and genetic code that regulate the above mechanism. These may also generate adaptive changes and resistance to drugs and disinfectants. The aim of the present review is to describe the structural and physiological implications of bacterial cell in the mechanisms of antibiotic resistance. The study also considered the structural and physiological organization involved in the main mechanisms of antibiotic resistance in bacteria relevant to clinical healthcare.

Artículo original

Proyecto DI17-0116 y Proyecto DI15-0070. Claudia Troncoso y Andres Santos agradecen a la Beca de Doctorado Nacional, Conicyt.

Proyecto DI17-0116 y Proyecto DI15-0070. Claudia Troncoso y Andrés Santos agradecen a la Beca de Doctorado Nacional, Conicyt.

10.4067/S0717-95022017000401214

pdf

Bacterial cell# Resistance# Antibiotics

http://dx.doi.org/10.4067/S0717-95022017000401214

Anatomy & Morphology

Célula bacteriana# Resistencia# antibióticos

Microbiología

Biología Celular

Farmacología y Farmacia

WOS:000428048400004

Structural and physiological implications of bacterial cell in antibiotic resistance mechanisms.

Artículo original

version publicada

SOC CHILENA ANATOMIA

INTERNATIONAL JOURNAL OF MORPHOLOGY

Anatomía y Morfología

0717-9502

es

UFRO DI17-0116#UFRO DI15-0070

ANID BECA DOCTORADO NACIONAL

UFRO DI17-0116

UFRO DI15-0070

Proyecto DI17-0116 y Proyecto DI15-0070. Claudia Troncoso y Andres Santos agradecen a la Beca de Doctorado Nacional, Conicyt.

pdf

dorada#verde

acceso abierto

acceso abierto

CC BY-NC

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